Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors


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We have previously shown that neuropeptide cycloprolylglycine (CPG) increases the content of brain-derived neurotrophic factor (BDNF) in the culture of neuronal cells under normal conditions and in pathology. This is the first study to show that CPG at a physiological concentration of 10–6 M significantly enhances the transmembrane AMPA currents in rat cerebellar Purkinje cells. Thus, CPG is a positive endogenous modulator of AMPA receptors. It was assumed that the neuropsychotropic effects of CPG are implemented as a result of BDNF accumulation after the activation of AMPA receptors by this neuropeptide.

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T. Gudasheva

Zakusov Research Institute of Pharmacology

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Email: tata-sosnovka@mail.ru
俄罗斯联邦, ul. Baltiiskaya 8, Moscow, 125315

V. Grigoriev

Institute of Physiologically Active Compounds

Email: tata-sosnovka@mail.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

K. Koliasnikova

Zakusov Research Institute of Pharmacology

Email: tata-sosnovka@mail.ru
俄罗斯联邦, ul. Baltiiskaya 8, Moscow, 125315

V. Zamoyski

Institute of Physiologically Active Compounds

Email: tata-sosnovka@mail.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

S. Seredenin

Zakusov Research Institute of Pharmacology

Email: tata-sosnovka@mail.ru
俄罗斯联邦, ul. Baltiiskaya 8, Moscow, 125315

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