Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway
- Авторы: Chernoryzh Y.Y.1, Fedorova N.E.1, Yurlov K.I.1, Simonov R.A.1, Kornev A.B.2, Karpov D.S.3, Zakirova N.F.3, Ivanov A.V.3, Kushch A.A.1, Gintsburg A.L.1,4
-
Учреждения:
- Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
- Выпуск: Том 489, № 1 (2019)
- Страницы: 388-391
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213122
- DOI: https://doi.org/10.1134/S1607672919060073
- ID: 213122
Цитировать
Аннотация
Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.
Об авторах
Ya. Chernoryzh
Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Россия, Moscow
N. Fedorova
Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Россия, Moscow
K. Yurlov
Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Россия, Moscow
R. Simonov
Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Россия, Moscow
A. Kornev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: vitallku@mail.ru
Россия, Chernogolovka, Moscow oblast
D. Karpov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: vitallku@mail.ru
Россия, Moscow
N. Zakirova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: vitallku@mail.ru
Россия, Moscow
A. Ivanov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: vitallku@mail.ru
Россия, Moscow
A. Kushch
Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: vitallku@mail.ru
Россия, Moscow
A. Gintsburg
Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation; The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Россия, Moscow; Moscow
Дополнительные файлы
