Encapsulation of Neurotoxins, Blockers of Nicotinic Acetylcholine Receptors, in Nanomaterials Based on Sulfated Polysaccharides
- Авторы: Nguyen T.D.1,2, Nguyen T.N.2,3, Nguyen K.C.1,2, Tran Q.N.1,2, Hoang A.N.1,2, Egorova N.S.4, Starkov V.G.4, Tsetlin V.I.4, Utkin Y.N.4
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Учреждения:
- Institute of Applied Materials Science, Vietnam Academy of Science and Technology
- Graduate University of Science and Technology, Vietnam Academy of Science and Technology
- Tra Vinh University
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Выпуск: Том 487, № 1 (2019)
- Страницы: 251-255
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213058
- DOI: https://doi.org/10.1134/S1607672919040021
- ID: 213058
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Аннотация
Three-finger snake neurotoxins are selective antagonists of some nicotinic acetylcholine receptor subtypes and are widely used to study these receptors. The peptide neurotoxin azemiopsin, recently isolated from the venom of Azemipos feae, is a selective blocker of muscle-type nicotinic acetylcholine receptor. In order to reduce their toxicity and increase resistance under physiological conditions, we have encapsulated these toxins into nanomaterials. The study of nanomaterials after interaction with neurotoxins by the methods of transmission electron microscopy and dynamic light scattering revealed an increase in the size of nanoparticles, which indicates the inclusion of neurotoxins in nanomaterials.
Об авторах
Tr. Nguyen
Institute of Applied Materials Science, Vietnam Academyof Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology
Email: yutkin@yandex.ru
Вьетнам, Ho Chi Minh City; Ho Chi Minh City
T. Nguyen
Graduate University of Science and Technology, Vietnam Academy of Science and Technology; Tra Vinh University
Email: yutkin@yandex.ru
Вьетнам, Ho Chi Minh City; Tra Vinh City
K. Nguyen
Institute of Applied Materials Science, Vietnam Academyof Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology
Email: yutkin@yandex.ru
Вьетнам, Ho Chi Minh City; Ho Chi Minh City
Q. Tran
Institute of Applied Materials Science, Vietnam Academyof Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology
Email: yutkin@yandex.ru
Вьетнам, Ho Chi Minh City; Ho Chi Minh City
A. Hoang
Institute of Applied Materials Science, Vietnam Academyof Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology
Email: yutkin@yandex.ru
Вьетнам, Ho Chi Minh City; Ho Chi Minh City
N. Egorova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: yutkin@yandex.ru
Россия, Moscow, 117997
V. Starkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: yutkin@yandex.ru
Россия, Moscow, 117997
V. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: yutkin@yandex.ru
Россия, Moscow, 117997
Yu. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: yutkin@yandex.ru
Россия, Moscow, 117997
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