The level of cytokines and expression of caspase genes in rheumatoid arthritis


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The level of TNFα and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients without MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the RA patients with MT therapy compared to the patients without MT therapy.

Sobre autores

I. Malysheva

Institute of Biology, Karelian Research Center

Autor responsável pela correspondência
Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910

L. Topchieva

Institute of Biology, Karelian Research Center

Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910

O. Barysheva

Petrozavodsk State University

Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910

I. Kurbatova

Institute of Biology, Karelian Research Center

Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910

O. Vasykova

Petrozavodsk State University

Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910

N. Vezikova

Petrozavodsk State University

Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910

I. Marusenko

Petrozavodsk State University

Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910

N. Nemova

Institute of Biology, Karelian Research Center

Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910

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