The level of cytokines and expression of caspase genes in rheumatoid arthritis
- Autores: Malysheva I.E.1, Topchieva L.V.1, Barysheva O.Y.2, Kurbatova I.V.1, Vasykova O.A.2, Vezikova N.N.2, Marusenko I.M.2, Nemova N.N.1
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Afiliações:
- Institute of Biology, Karelian Research Center
- Petrozavodsk State University
- Edição: Volume 468, Nº 1 (2016)
- Páginas: 226-228
- Seção: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211324
- DOI: https://doi.org/10.1134/S1607672916030194
- ID: 211324
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Resumo
The level of TNFα and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients without MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the RA patients with MT therapy compared to the patients without MT therapy.
Sobre autores
I. Malysheva
Institute of Biology, Karelian Research Center
Autor responsável pela correspondência
Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910
L. Topchieva
Institute of Biology, Karelian Research Center
Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910
O. Barysheva
Petrozavodsk State University
Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910
I. Kurbatova
Institute of Biology, Karelian Research Center
Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910
O. Vasykova
Petrozavodsk State University
Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910
N. Vezikova
Petrozavodsk State University
Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910
I. Marusenko
Petrozavodsk State University
Email: i.e.malysheva@yandex.ru
Rússia, pr. Lenina 33, Petrozavodsk, Karelia, 185910
N. Nemova
Institute of Biology, Karelian Research Center
Email: i.e.malysheva@yandex.ru
Rússia, ul. Pushkinskaya 11, Petrozavodsk, 185910
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