Digoxin is a selective modifier increasing platinum drug anticancer activity
- Авторы: Bogush T.A.1, Chernov V.Y.2, Dudko E.A.1, Shprakh Z.S.1, Bogush E.A.1, Polotsky B.E.1, Tjulandin S.A.1, Davydov M.I.1
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Учреждения:
- N.N. Blokhin Russian Cancer Research Center
- Faculty of Biology
- Выпуск: Том 468, № 1 (2016)
- Страницы: 220-223
- Раздел: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211299
- DOI: https://doi.org/10.1134/S1607672916030170
- ID: 211299
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Аннотация
Using the model of breast cancer Ehrlich ascites tumor in mice, we showed that a sigle intraperitoneal injection of cardiac glycoside digoxin 1 h before the intraperitoneal injection of cisplatin increased the anticancer effect of the cytostatic drug more than twice when recalculated for the dose. It is assumed that the modifying effect of digoxin is determined by the direct inhibition of glycolysis in tumor cells. Taking into account the design of the study, we consider promising the clinical evaluation of the effectiveness of digoxin as a modifier of cisplatin efficiency in intracavitary therapy of ascites cancers with pleural and abdominal dissenmination.
Об авторах
T. Bogush
N.N. Blokhin Russian Cancer Research Center
Автор, ответственный за переписку.
Email: tatbogush@mail.ru
Россия, Kashirskoe sh. 24, Moscow, 115478
V. Chernov
Faculty of Biology
Email: tatbogush@mail.ru
Россия, Moscow, 119991
E. Dudko
N.N. Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Россия, Kashirskoe sh. 24, Moscow, 115478
Z. Shprakh
N.N. Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Россия, Kashirskoe sh. 24, Moscow, 115478
E. Bogush
N.N. Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Россия, Kashirskoe sh. 24, Moscow, 115478
B. Polotsky
N.N. Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Россия, Kashirskoe sh. 24, Moscow, 115478
S. Tjulandin
N.N. Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Россия, Kashirskoe sh. 24, Moscow, 115478
M. Davydov
N.N. Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Россия, Kashirskoe sh. 24, Moscow, 115478
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