Highly immunogenic variant of attenuated vaccinia virus
- Autores: Yakubitskyi S.N.1, Kolosova I.V.1, Maksyutov R.A.1, Shchelkunov S.N.1
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Afiliações:
- Vector State Research Center of Virology and Biotechnology
- Edição: Volume 466, Nº 1 (2016)
- Páginas: 35-38
- Seção: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/210981
- DOI: https://doi.org/10.1134/S1607672916010105
- ID: 210981
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Resumo
The LIVPΔ6 strain of vaccinia virus (VACV) was created by genetic engineering on the basis of previously obtained attenuated 1421ABJCN strain by target deletion of the A35R gene encoding an inhibitor of antigen presentation by the major histocompatibility complex class II. 1421ABJCN is the LIVP strain of VACV with five inactivated virulence genes encoding hemagglutinin (A56R), γ-interferon-binding protein (B8R), thymidine kinase (J2R), complement-binding protein (C3L), and Bcl2-like inhibitor of apoptosis (N1L). The highly immunogenic LIVPΔ6 strain could be an efficient fourth-generation attenuated vaccine against smallpox and other orthopoxvirus infections.
Sobre autores
S. Yakubitskyi
Vector State Research Center of Virology and Biotechnology
Autor responsável pela correspondência
Email: snshchel@vector.nsc.ru
Rússia, Koltsovo, Novosibirsk oblast, 633159
I. Kolosova
Vector State Research Center of Virology and Biotechnology
Email: snshchel@vector.nsc.ru
Rússia, Koltsovo, Novosibirsk oblast, 633159
R. Maksyutov
Vector State Research Center of Virology and Biotechnology
Email: snshchel@vector.nsc.ru
Rússia, Koltsovo, Novosibirsk oblast, 633159
S. Shchelkunov
Vector State Research Center of Virology and Biotechnology
Email: snshchel@vector.nsc.ru
Rússia, Koltsovo, Novosibirsk oblast, 633159
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