Enviar artigo por via de e-mail Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages
- Autores: Krutetskaya Z.I.1, Milenina L.S.1, Antonov V.G.1, Nozdrachev A.D.1,2
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Afiliações:
- St. Petersburg State University
- Institute of Physiology, Russian Academy of Sciences
- Edição: Volume 488, Nº 1 (2019)
- Páginas: 307-310
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213077
- DOI: https://doi.org/10.1134/S1607672919050041
- ID: 213077
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Resumo
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist–tricyclic antidepressant amitriptyline—significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.
Sobre autores
Z. Krutetskaya
St. Petersburg State University
Autor responsável pela correspondência
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg
L. Milenina
St. Petersburg State University
Email: a.d.nozdrachev@mail.ru
Rússia, St. Petersburg
V. Antonov
St. Petersburg State University
Email: a.d.nozdrachev@mail.ru
Rússia, St. Petersburg
A. Nozdrachev
St. Petersburg State University; Institute of Physiology, Russian Academy of Sciences
Autor responsável pela correspondência
Email: a.d.nozdrachev@mail.ru
Rússia, St. Petersburg;
St. Petersburg
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