Dynamics of in Vivo Metabolites Concentrations in Posttraumatic Period of Human Brain. 1H MRS Study


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Аннотация

For the first time the intracellular concentrations of N-acetylaspartate (NAA), aspartate (Asp), and glutamate (Glu) were measured in human brain in vivo, and the effect of severe traumatic brain injury on NAA synthesis in acute and remote posttraumatic phases was revealed. In non-damaged (MRI-negative) lobes the next day after injury, Asp and Glu decreased by 45% and 35%, respectively, while NAA decreased only by 16%. A negative correlation between NAA and Asp/Glu ratio was found. The Glu level returned to the norm long after injury, Asp remained below the norm by 60%, NAA decreased by 65% relative to the norm, and Asp/Glu decreased significantly. The results obtained educe the leading role of neuronal aspartate–malate shuttle in NAA synthesis alterations.

Авторлар туралы

N. Semenova

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Semenov Institute of Chemical Physics, Russian Academy
of Sciences; Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology

Email: Andrey.man.93@gmail.com
Ресей, Moscow, 119334; Moscow, 119991; Moscow, 127412

P. Menshchikov

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Semenov Institute of Chemical Physics, Russian Academy
of Sciences; Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology

Email: Andrey.man.93@gmail.com
Ресей, Moscow, 119334; Moscow, 119991; Moscow, 127412

A. Manzhurtsev

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology

Хат алмасуға жауапты Автор.
Email: Andrey.man.93@gmail.com
Ресей, Moscow, 119334; Moscow, 127412

M. Ublinskiy

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology

Email: Andrey.man.93@gmail.com
Ресей, Moscow, 119334; Moscow, 127412

T. Akhadov

Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology

Email: Andrey.man.93@gmail.com
Ресей, Moscow, 127412

S. Varfolomeev

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Chemical Faculty, Moscow State University

Email: Andrey.man.93@gmail.com
Ресей, Moscow, 119334; Moscow, 119991

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