Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts


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The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

Sobre autores

A. Gizatullin

Institute of Problems of Chemical Physics

Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast

N. Akentieva

Institute of Problems of Chemical Physics

Autor responsável pela correspondência
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast

N. Sanina

Institute of Problems of Chemical Physics; Moscow State University

Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast; Moscow, 119991

N. Shmatko

Institute of Problems of Chemical Physics

Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast

N. Goryachev

Institute of Problems of Chemical Physics; Moscow State University

Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast; Moscow, 119991

N. Shkondina

Institute of Problems of Chemical Physics

Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast

T. Prichodchenko

Institute of Problems of Chemical Physics

Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast

N. Zhelev

Abertay University

Email: na_aken@icp.ac.ru
Reino Unido da Grã-Bretanha e Irlanda do Norte, Dundee

S. Aldoshin

Institute of Problems of Chemical Physics; Moscow State University

Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast; Moscow, 119991

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