Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts
- Autores: Gizatullin A.R.1, Akentieva N.P.1, Sanina N.A.1,2, Shmatko N.Y.1, Goryachev N.S.1,2, Shkondina N.I.1, Prichodchenko T.R.1, Zhelev N.3, Aldoshin S.M.1,2
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Afiliações:
- Institute of Problems of Chemical Physics
- Moscow State University
- Abertay University
- Edição: Volume 483, Nº 1 (2018)
- Páginas: 337-340
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212566
- DOI: https://doi.org/10.1134/S1607672918060133
- ID: 212566
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Resumo
The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.
Sobre autores
A. Gizatullin
Institute of Problems of Chemical Physics
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast
N. Akentieva
Institute of Problems of Chemical Physics
Autor responsável pela correspondência
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast
N. Sanina
Institute of Problems of Chemical Physics; Moscow State University
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast; Moscow, 119991
N. Shmatko
Institute of Problems of Chemical Physics
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast
N. Goryachev
Institute of Problems of Chemical Physics; Moscow State University
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast; Moscow, 119991
N. Shkondina
Institute of Problems of Chemical Physics
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast
T. Prichodchenko
Institute of Problems of Chemical Physics
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast
N. Zhelev
Abertay University
Email: na_aken@icp.ac.ru
Reino Unido da Grã-Bretanha e Irlanda do Norte, Dundee
S. Aldoshin
Institute of Problems of Chemical Physics; Moscow State University
Email: na_aken@icp.ac.ru
Rússia, Chernogolovka, Moscow oblast; Moscow, 119991
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