Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis: From Fundamental Biology to Development of New Target-Specific Drugs
- Авторы: Shvets V.I.1,2,3, Krasavin M.Y.4, Gureev M.A.1,5, Garabadzhiu A.V.1, Pashkin A.Y.6, Zhukov A.S.6, Khairutdinov V.R.6, Samtsov A.V.6
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Учреждения:
- St. Petersburg State Technological Institute (Technical University)
- Lomonosov Institute of Fine Chemical Technologies MIREA, Russian Technological University
- Research Institute of General Pathology and Pathophysiology
- St. Petersburg State University
- Sechenov First Moscow State Medical University
- Kirov Military Medical Academy
- Выпуск: Том 487, № 1 (2019)
- Страницы: 272-276
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213065
- DOI: https://doi.org/10.1134/S1607672919040082
- ID: 213065
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Аннотация
Psoriasis therapy remains an extremely relevant area of modern drug design, due to necessity of adverse reaction reduction, inherent for actual methods of therapy. It was established that two serine proteases—neutrophil elastase 1 (HNE1) and cathepsin G (CatG)—are the key agents in psoriasis development. The collected molecular data for the presented targets form the basis for the molecular modeling strategy for the search for and identification of new target-specific inhibitors. The result of this work is a group of high-priority small-molecule compounds with double-targeted affinity, which are able to suppress the pro-psoriatic processes induced by the considered serine proteases at the initial stage of the disease.
Об авторах
V. Shvets
St. Petersburg State Technological Institute (Technical University); Lomonosov Institute of Fine Chemical Technologies MIREA, Russian Technological University; Research Institute of General Pathology and Pathophysiology
Email: gar-54@mail.ru
Россия, St. Petersburg, 190013; Moscow, 119454; Moscow, 125315
M. Krasavin
St. Petersburg State University
Email: gar-54@mail.ru
Россия, St. Petersburg, 199034
M. Gureev
St. Petersburg State Technological Institute (Technical University); Sechenov First Moscow State Medical University
Email: gar-54@mail.ru
Россия, St. Petersburg, 190013; Moscow, 119991
A. Garabadzhiu
St. Petersburg State Technological Institute (Technical University)
Автор, ответственный за переписку.
Email: gar-54@mail.ru
Россия, St. Petersburg, 190013
A. Pashkin
Kirov Military Medical Academy
Email: gar-54@mail.ru
Россия, St. Petersburg,
194044
A. Zhukov
Kirov Military Medical Academy
Email: gar-54@mail.ru
Россия, St. Petersburg,
194044
V. Khairutdinov
Kirov Military Medical Academy
Email: gar-54@mail.ru
Россия, St. Petersburg,
194044
A. Samtsov
Kirov Military Medical Academy
Email: gar-54@mail.ru
Россия, St. Petersburg,
194044
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