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Novel efficient promoter of the mitochondrial porin, voltage-dependent anion channel (VDAC), in the genome of the Yarrowia lipolytica yeast


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Abstract

This article presents the characteristics of the highly inducible promoter of the gene encoding the mitochondrial porin, the voltage-dependent anion channel (VDAC). This promoter is recommended for use in new genetic constructs both in basic research for assessing the adaptive strategy of lower eukaryotes under adverse conditions and in designing new highly competitive transformants producing economically important compounds (proteins, lipids, and organic acids) on its basis.

About the authors

F. F. Kulanbaewa

Mendeleev University of Chemical Technology

Email: yul_der@mail.ru
Russian Federation, Miusskaya pl. 9, Moscow, 125190

V. Yu. Sekova

Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology,”

Email: yul_der@mail.ru
Russian Federation, Leninskii pr. 33, Moscow, 119071

E. P. Isakova

Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology,”

Email: yul_der@mail.ru
Russian Federation, Leninskii pr. 33, Moscow, 119071

Y. I. Deryabina

Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology,”

Author for correspondence.
Email: yul_der@mail.ru
Russian Federation, Leninskii pr. 33, Moscow, 119071

A. V. Nikolaev

Schmidt Joint Institute of Physics of the Earth

Email: yul_der@mail.ru
Russian Federation, ul. Bol’shaya Gruzinskaya 10, Moscow, 123810

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