New monoclonal antibodies to the Ebola virus glycoprotein: Identification and analysis of the amino acid sequence of the variable domains

A. A. Panina; T. K. Aliev; O. B. Shemchukova; I. G. Dement’yeva; N. E. Varlamov; L. P. Pozdnyakova; M. N. Bokov; D. A. Dolgikh; P. G. Sveshnikov; M. P. Kirpichnikov

doi:10.1134/S1607672916020113

New monoclonal antibodies to the Ebola virus glycoprotein: Identification and analysis of the amino acid sequence of the variable domains

Авторлар: Panina A.A.¹, Aliev T.K.², Shemchukova O.B.³, Dement’yeva I.G.³, Varlamov N.E.³, Pozdnyakova L.P.³, Bokov M.N.³, Dolgikh D.A.¹^,4, Sveshnikov P.G.³, Kirpichnikov M.P.¹^,4
Мекемелер:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
2. Faculty of Chemistry
3. All-Russia Research Center of Molecular Diagnostics and Therapy
4. Faculty of Biology
Шығарылым: Том 467, № 1 (2016)
Беттер: 117-120
Бөлім: Biochemistry, Biophysics and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211050
DOI: https://doi.org/10.1134/S1607672916020113
ID: 211050

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Аннотация

We determined the nucleotide and amino acid sequences of variable domains of three new monoclonal antibodies to the glycoprotein of Ebola virus capsid. The framework and hypervariable regions of immunoglobulin heavy and light chains were identified. The primary structures were confirmed using massspectrometry analysis. Immunoglobulin database search showed the uniqueness of the sequences obtained.