N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress

A. M. Ashba; M. G. Akimov; N. M. Gretskaya; V. V. Bezuglov

doi:10.1134/S1607672916020010

N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress

作者: Ashba A.M.¹, Akimov M.G.¹, Gretskaya N.M.¹, Bezuglov V.V.¹
隶属关系:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
期: 卷 467, 编号 1 (2016)
页面: 81-84
栏目: Biochemistry, Biophysics and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211013
DOI: https://doi.org/10.1134/S1607672916020010
ID: 211013

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详细

It was shown that dopamine amides of arachidonic, oleic, and docosahexaenoic acids exhibit toxicity with respect to PC12 pheochromocytoma cell line. The mechanism of realization of the cytotoxic effect of acyl dopamines is the induction of oxidative stress. This event is preceded by triggering the synthesis of nitric oxide.