Email this article CTCF and Sgfl1 proteins form alternative complexes with ENY2 proteins
- Authors: Bonchuk A.N.1, Georgiev P.G.1, Maksimenko O.G.1
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Affiliations:
- Institute of Gene Biology
- Issue: Vol 468, No 1 (2016)
- Pages: 180-182
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211203
- DOI: https://doi.org/10.1134/S1607672916030054
- ID: 211203
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Abstract
ENY2 is a multifunctional protein, a component of the SAGA complex (protein complex involved in the regulation of transcription, possessing histone-acetyltransferase and H2B-histone-deubiquitinylating activities [1]) and TREX-2 (complex involved in the mRNA nuclear export [2]). Besides this, the interactions of ENY2 with DNA-binding insulator proteins Su(Hw) and dCTCF have been described as essential for the barrier activity of corresponding insulators [3, 4]. In this study, we described the formation of mutually exclusive complexes of ENY2 with insulator proteins and Sgfl1—a component of the SAGA complex, direct binding partner for ENY2.
About the authors
A. N. Bonchuk
Institute of Gene Biology
Author for correspondence.
Email: errinaceus@rambler.ru
Russian Federation, ul. Vavilova 34/5, Moscow, 119334
P. G. Georgiev
Institute of Gene Biology
Email: errinaceus@rambler.ru
Russian Federation, ul. Vavilova 34/5, Moscow, 119334
O. G. Maksimenko
Institute of Gene Biology
Email: errinaceus@rambler.ru
Russian Federation, ul. Vavilova 34/5, Moscow, 119334
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