Enviar artigo por via de e-mail Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes
- Autores: Maluchenko N.V.1, Sultanov D.S.2, Kotova E.Y.2, Kirpichnikov M.P.1,3, Studitsky V.M.1,2, Feofanov A.V.1,3
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Afiliações:
- Moscow State University
- Fox Chase Cancer Center
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Edição: Volume 489, Nº 1 (2019)
- Páginas: 377-379
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213116
- DOI: https://doi.org/10.1134/S1607672919060061
- ID: 213116
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Resumo
PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.
Sobre autores
N. Maluchenko
Moscow State University
Autor responsável pela correspondência
Email: mal_nat@mail.ru
Rússia, Moscow, 119234
D. Sultanov
Fox Chase Cancer Center
Email: mal_nat@mail.ru
Estados Unidos da América, Philadelphia
E. Kotova
Fox Chase Cancer Center
Email: mal_nat@mail.ru
Estados Unidos da América, Philadelphia
M. Kirpichnikov
Moscow State University; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mal_nat@mail.ru
Rússia, Moscow, 119234; Moscow, 117997
V. Studitsky
Moscow State University; Fox Chase Cancer Center
Email: mal_nat@mail.ru
Rússia, Moscow, 119234; Philadelphia
A. Feofanov
Moscow State University; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mal_nat@mail.ru
Rússia, Moscow, 119234; Moscow, 117997
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