Removal of the Translocation Domain and the Furin Cleavage Site Decreases the Relative Hepatotoxicity of the Targeted Antitumor Toxins
- Авторлар: Khodarovich Y.M.1, Konovalova E.V.1, Schulga A.A.1, Deyev S.M.1, Petrov R.V.1
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Мекемелер:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Шығарылым: Том 489, № 1 (2019)
- Беттер: 370-372
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213112
- DOI: https://doi.org/10.1134/S1607672919060048
- ID: 213112
Дәйексөз келтіру
Аннотация
Targeted toxins are promising anticancer agents that allow selectively destroying cancer cells due to the increased content of onco-specific markers on their surface. The use of such anti-cancer toxins in medicine is mainly hampered by their high non-specific toxicity, in particular, hepatotoxicity. In our work on human cell line, we have shown that the removal of the DARPin-PE40 translocation toxin domain leads to a decrease in hepatotoxicity. The same effect is also observed when inactivation of the furin cleavage site in the DARPin-PE40 molecule was done. Simultaneous removal of both the translocation domain and the furin cleavage site showed the best results. This toxin modification can be used to create more selective anti-cancer toxins.
Авторлар туралы
Yu. Khodarovich
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: khodarovich@mail.ru
Ресей, Moscow, 117997
E. Konovalova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: khodarovich@mail.ru
Ресей, Moscow, 117997
A. Schulga
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: khodarovich@mail.ru
Ресей, Moscow, 117997
S. Deyev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: khodarovich@mail.ru
Ресей, Moscow, 117997
R. Petrov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: khodarovich@mail.ru
Ресей, Moscow, 117997
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