The Antiproliferative Effect of the “Early” Protein E2 of Papillomavirus HPV16 on Testis Tumors of Mice Induced by the Injection of HeLa Cells
- Авторлар: Salyaev R.K.1,2, Rekoslavskaya N.I.1,2, Stolbikov A.S.1,2
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Мекемелер:
- Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences
- Irkutsk Scientific Center, Siberian Branch, Russian Academy of Sciences
- Шығарылым: Том 488, № 1 (2019)
- Беттер: 296-299
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213073
- DOI: https://doi.org/10.1134/S1607672919050028
- ID: 213073
Дәйексөз келтіру
Аннотация
The antiproliferative effect of the “early” protein E2 of the high-risk oncogenic human papillomavirus HPV16 on mouse testis tumors, which were induced by the intramuscular injection of HeLa cells, was discovered. The regression of tumors was maximum in the first 2 days after the oral vaccination with HPV16 E2 (500 mg per mouse) and then gradually decreased to the control variant. A typical monolayer of HeLa cells on the cultivation flask bottom, of which only 18% were functionally active, appeared after seeding testis tissue cells on DMEM medium.
Авторлар туралы
R. Salyaev
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: salyaev@sifibr.irk.ru
Ресей, Irkutsk, 664033; Irkutsk, 664033
N. Rekoslavskaya
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,Russian Academy of Sciences
Email: salyaev@sifibr.irk.ru
Ресей, Irkutsk, 664033; Irkutsk, 664033
A. Stolbikov
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,Russian Academy of Sciences
Email: salyaev@sifibr.irk.ru
Ресей, Irkutsk, 664033; Irkutsk, 664033
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