The Antiproliferative Effect of the “Early” Protein E2 of Papillomavirus HPV16 on Testis Tumors of Mice Induced by the Injection of HeLa Cells


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Аннотация

The antiproliferative effect of the “early” protein E2 of the high-risk oncogenic human papillomavirus HPV16 on mouse testis tumors, which were induced by the intramuscular injection of HeLa cells, was discovered. The regression of tumors was maximum in the first 2 days after the oral vaccination with HPV16 E2 (500 mg per mouse) and then gradually decreased to the control variant. A typical monolayer of HeLa cells on the cultivation flask bottom, of which only 18% were functionally active, appeared after seeding testis tissue cells on DMEM medium.

Авторлар туралы

R. Salyaev

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,
Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: salyaev@sifibr.irk.ru
Ресей, Irkutsk, 664033; Irkutsk, 664033

N. Rekoslavskaya

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,
Russian Academy of Sciences

Email: salyaev@sifibr.irk.ru
Ресей, Irkutsk, 664033; Irkutsk, 664033

A. Stolbikov

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,
Russian Academy of Sciences

Email: salyaev@sifibr.irk.ru
Ресей, Irkutsk, 664033; Irkutsk, 664033

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