Email this article NSP Protein Encoded in Negative NS RNA Strand of Influenza A Virus Induces Cellular Immune Response in Infected Animals
- Authors: Zhirnov O.P.1,2, Isaeva E.I.1
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Affiliations:
- Ivanovsky Institute of Virology, Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation
- Russian–German Academy of Medical and Biotechnological Sciences
- Issue: Vol 486, No 1 (2019)
- Pages: 201-205
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213014
- DOI: https://doi.org/10.1134/S1607672919030128
- ID: 213014
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Abstract
Infection of mice with influenza A viruses led to the formation of clones of lymphocytes that specifically recognizes viral domains in the central zone of the NSP protein (amino acid positions 83–119). Computer analysis of the primary structure of the NSP protein showed the presence of T-cell epitopes in the central part of the NSP molecule. The findings indicate that the viral NSP gene is expressed in the infected animals and verify the concept of the bipolar strategy (ambisense strategy) of the influenza A virus genome.
About the authors
O. P. Zhirnov
Ivanovsky Institute of Virology, Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Healthcareof the Russian Federation; Russian–German Academy of Medical and Biotechnological Sciences
Author for correspondence.
Email: zhirnov@inbox.ru
Russian Federation, Moscow, 123098; Moscow, 142782
E. I. Isaeva
Ivanovsky Institute of Virology, Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Healthcareof the Russian Federation
Email: zhirnov@inbox.ru
Russian Federation, Moscow, 123098
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