Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast
- Авторлар: Autenshlyus A.I.1,2, Golovanova A.V.1, Studenikina A.A.1, Brusentsov I.I.3, Proskura A.V.2, Zhurakovskiy I.P.1, Arkhipov S.A.1,2, Sidorov S.V.4, Vavilin V.A.2, Lyakhovich V.V.2
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Мекемелер:
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Research Institute of Molecular Biology and Biophysics
- Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
- National Research Novosibirsk State University
- Шығарылым: Том 484, № 1 (2019)
- Беттер: 59-62
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212759
- DOI: https://doi.org/10.1134/S1607672919010162
- ID: 212759
Дәйексөз келтіру
Аннотация
Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.
Авторлар туралы
A. Autenshlyus
Novosibirsk State Medical University, Ministry of Healthof the Russian Federation; Research Institute of Molecular Biology and Biophysics
Хат алмасуға жауапты Автор.
Email: lpciip@211.ru
Ресей, Novosibirsk, 630091; Novosibirsk, 630117
A. Golovanova
Novosibirsk State Medical University, Ministry of Healthof the Russian Federation
Email: lpciip@211.ru
Ресей, Novosibirsk, 630091
A. Studenikina
Novosibirsk State Medical University, Ministry of Healthof the Russian Federation
Email: lpciip@211.ru
Ресей, Novosibirsk, 630091
I. Brusentsov
Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences
Email: lpciip@211.ru
Ресей, Novosibirsk, 630090
A. Proskura
Research Institute of Molecular Biology and Biophysics
Email: lpciip@211.ru
Ресей, Novosibirsk, 630117
I. Zhurakovskiy
Novosibirsk State Medical University, Ministry of Healthof the Russian Federation
Email: lpciip@211.ru
Ресей, Novosibirsk, 630091
S. Arkhipov
Novosibirsk State Medical University, Ministry of Healthof the Russian Federation; Research Institute of Molecular Biology and Biophysics
Email: lpciip@211.ru
Ресей, Novosibirsk, 630091; Novosibirsk, 630117
S. Sidorov
National Research Novosibirsk State University
Email: lpciip@211.ru
Ресей, Novosibirsk, 630090
V. Vavilin
Research Institute of Molecular Biology and Biophysics
Email: lpciip@211.ru
Ресей, Novosibirsk, 630117
V. Lyakhovich
Research Institute of Molecular Biology and Biophysics
Email: lpciip@211.ru
Ресей, Novosibirsk, 630117
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