A Novel PRE-Element from Drosophila virilis Genome as a Useful Model Silencer
- Авторлар: Chetverina D.A.1, Mikhailova A.V.1, Georgiev P.G.1, Erokhin M.M.1
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Мекемелер:
- Institute of Gene Biology, Russian Academy of Sciences
- Шығарылым: Том 484, № 1 (2019)
- Беттер: 33-36
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212706
- DOI: https://doi.org/10.1134/S1607672919010095
- ID: 212706
Дәйексөз келтіру
Аннотация
We tested the activity of the PRE element from the Drosophila virilis genome, which is the homologue of the known Drosophila melanogasterbxdPRE element from the regulatory region of the Ubx gene. It is easy to select unique primers to this element that do not occur in the Drosophila melanogaster genome. We showed that the studied PRE element causes a strong repression of the white marker gene upon insertion into the Drosophila melanogaster genome and interacts with the PcG proteins of the PRC1 and PhoRC complexes.
Авторлар туралы
D. Chetverina
Institute of Gene Biology, Russian Academy of Sciences
Email: yermaxbio@yandex.ru
Ресей, Moscow, 119334
A. Mikhailova
Institute of Gene Biology, Russian Academy of Sciences
Email: yermaxbio@yandex.ru
Ресей, Moscow, 119334
P. Georgiev
Institute of Gene Biology, Russian Academy of Sciences
Email: yermaxbio@yandex.ru
Ресей, Moscow, 119334
M. Erokhin
Institute of Gene Biology, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: yermaxbio@yandex.ru
Ресей, Moscow, 119334
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