Anticholinesterase and Antioxidant Activity of New Binary Conjugates of γ-Carbolines
- Авторлар: Makhaeva G.F.1, Shevtsova E.F.1, Boltneva N.P.1, Kovaleva N.V.1, Rudakova E.V.1, Dubova L.G.1, Shevtsov P.N.1, Bachurin S.O.1
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Мекемелер:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Шығарылым: Том 484, № 1 (2019)
- Беттер: 1-5
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212672
- DOI: https://doi.org/10.1134/S1607672919010010
- ID: 212672
Дәйексөз келтіру
Аннотация
The synthesized new binary conjugates of tetrahydro-γ-carbolines, which contained ditriazole spacers of different length, exhibited considerable anticholinesterase and antioxidant activity as well as the potential ability to block the acetylcholinesterase-induced aggregation of β-amyloid in contrast to the original prototype Dimebon. This makes the compounds promising candidates for further investigation as drugs for the treatment of Alzheimer’s disease. Special attention should be given to the conjugate containing the hexamethylene intertriazole spacer, which can be considered as a leader in this series of compounds.
Авторлар туралы
G. Makhaeva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: gmakh@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
E. Shevtsova
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: shevtsova@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
N. Boltneva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: shevtsova@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
N. Kovaleva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: shevtsova@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
E. Rudakova
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: shevtsova@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
L. Dubova
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: shevtsova@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
P. Shevtsov
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: shevtsova@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
S. Bachurin
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: shevtsova@ipac.ac.ru
Ресей, Chernogolovka,
Moscow oblast, 142432
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