Neonatal Lethality and Inflammatory Phenotype of the New Transgenic Mice with Overexpression of Human Interleukin-6 in Myeloid Cells


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Resumo

To model human interleukin-6 (hIL-6) associated diseases, unique mice with transgenic overexpression of human IL-6 and reporter fluorescent protein EGFP in cells of macrophage-monocyte lineage were generated using loxP–Cre system. High level of hIL-6 production by macrophages and monocytes, as confirmed in vitro in primary culture of bone marrow-derived macrophages, in vivo resulted in early postnatal death in vivo, presumably, due to the effect of overexpression of hIL-6 on hematopoiesis.

Sobre autores

R. Zvartsev

Engelhardt Institute of Molecular Biology

Email: marinadru@gmail.ru
Rússia, Moscow

D. Korshunova

Institute of Gene Biology

Email: marinadru@gmail.ru
Rússia, Moscow

E. Gorshkova

Engelhardt Institute of Molecular Biology; Department of Immunology, Biological Faculty

Email: marinadru@gmail.ru
Rússia, Moscow; Moscow, 119991

M. Nosenko

Engelhardt Institute of Molecular Biology; Department of Immunology, Biological Faculty

Email: marinadru@gmail.ru
Rússia, Moscow; Moscow, 119991

K. Korneev

Engelhardt Institute of Molecular Biology; Department of Immunology, Biological Faculty

Email: marinadru@gmail.ru
Rússia, Moscow; Moscow, 119991

O. Maksimenko

Institute of Gene Biology

Email: marinadru@gmail.ru
Rússia, Moscow

I. Korobko

Institute of Gene Biology

Email: marinadru@gmail.ru
Rússia, Moscow

D. Kuprash

Engelhardt Institute of Molecular Biology; Department of Immunology, Biological Faculty

Email: marinadru@gmail.ru
Rússia, Moscow; Moscow, 119991

M. Drutskaya

Engelhardt Institute of Molecular Biology; Department of Immunology, Biological Faculty

Autor responsável pela correspondência
Email: marinadru@gmail.ru
Rússia, Moscow; Moscow, 119991

S. Nedospasov

Engelhardt Institute of Molecular Biology; Department of Immunology, Biological Faculty

Email: marinadru@gmail.ru
Rússia, Moscow; Moscow, 119991

A. Deikin

Institute of Gene Biology

Email: marinadru@gmail.ru
Rússia, Moscow

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