The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre Recombinase


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Resumo

In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre–LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.

Sobre autores

O. Bezborodova

Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology

Autor responsável pela correspondência
Email: olgabezborodova@yandex.ru
Rússia, Moscow, 125284

I. Alekseenko

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Molecular Genetics

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 117997; Moscow, 123182

E. Nemtsova

Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 125284

A. Pankratov

Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 125284

O. Filyukova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 117997

R. Yakubovskaya

Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 125284

M. Kostina

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 117997

V. Potapov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 117997

E. Sverdlov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Molecular Genetics

Email: olgabezborodova@yandex.ru
Rússia, Moscow, 117997; Moscow, 123182

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