Email this article The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre Recombinase
- Authors: Bezborodova O.A.1, Alekseenko I.V.2,3, Nemtsova E.R.1, Pankratov A.A.1, Filyukova O.B.2, Yakubovskaya R.I.1, Kostina M.B.2, Potapov V.K.2, Sverdlov E.D.2,3
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Affiliations:
- Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Institute of Molecular Genetics
- Issue: Vol 483, No 1 (2018)
- Pages: 326-328
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212545
- DOI: https://doi.org/10.1134/S1607672918060091
- ID: 212545
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Abstract
In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre–LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.
About the authors
O. A. Bezborodova
Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology
Author for correspondence.
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 125284
I. V. Alekseenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Molecular Genetics
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 117997; Moscow, 123182
E. R. Nemtsova
Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 125284
A. A. Pankratov
Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 125284
O. B. Filyukova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 117997
R. I. Yakubovskaya
Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 125284
M. B. Kostina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 117997
V. K. Potapov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 117997
E. D. Sverdlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Molecular Genetics
Email: olgabezborodova@yandex.ru
Russian Federation, Moscow, 117997; Moscow, 123182
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