Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors
- Autores: Kryukova E.V.1, Ivanov I.A.1, Lebedev D.S.1, Spirova E.N.1, Senko D.A.1, Egorova N.S.1, Kasheverov I.E.1,2, Tsetlin V.I.1
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Afiliações:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Sechenov First Moscow State Medical University
- Edição: Volume 483, Nº 1 (2018)
- Páginas: 313-315
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212529
- DOI: https://doi.org/10.1134/S1607672918060017
- ID: 212529
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Resumo
Arginine-containing peptides R3, R8, and R16 were obtained by solid-phase peptide synthesis, and their binding to nicotinic acetylcholine receptors (nAChRs) of muscle and neuronal (α7) types was studied by competitive radioligand assay with the use of 125I-α-bungarotoxin. The resulting peptides exhibited a significantly greater binding activity with respect to the muscle-type nAChRs than to the α7 receptor. Thus, we have discovered a new class of nAChR ligands. The affinity of the synthesized oligoarginines for nAChR depended on the number of amino acid residues in the chain. The highest affinity was exhibited by the R16 peptide, which contained 16 arginine residues.
Sobre autores
E. Kryukova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Autor responsável pela correspondência
Email: evkr@mail.ru
Rússia, Moscow, 117997
I. Ivanov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: evkr@mail.ru
Rússia, Moscow, 117997
D. Lebedev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: evkr@mail.ru
Rússia, Moscow, 117997
E. Spirova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: evkr@mail.ru
Rússia, Moscow, 117997
D. Senko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: evkr@mail.ru
Rússia, Moscow, 117997
N. Egorova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: evkr@mail.ru
Rússia, Moscow, 117997
I. Kasheverov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Sechenov First Moscow State Medical University
Email: evkr@mail.ru
Rússia, Moscow, 117997; Moscow, 119992
V. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: evkr@mail.ru
Rússia, Moscow, 117997
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