Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

Arginine-containing peptides R3, R8, and R16 were obtained by solid-phase peptide synthesis, and their binding to nicotinic acetylcholine receptors (nAChRs) of muscle and neuronal (α7) types was studied by competitive radioligand assay with the use of 125I-α-bungarotoxin. The resulting peptides exhibited a significantly greater binding activity with respect to the muscle-type nAChRs than to the α7 receptor. Thus, we have discovered a new class of nAChR ligands. The affinity of the synthesized oligoarginines for nAChR depended on the number of amino acid residues in the chain. The highest affinity was exhibited by the R16 peptide, which contained 16 arginine residues.

Sobre autores

E. Kryukova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Autor responsável pela correspondência
Email: evkr@mail.ru
Rússia, Moscow, 117997

I. Ivanov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: evkr@mail.ru
Rússia, Moscow, 117997

D. Lebedev

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: evkr@mail.ru
Rússia, Moscow, 117997

E. Spirova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: evkr@mail.ru
Rússia, Moscow, 117997

D. Senko

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: evkr@mail.ru
Rússia, Moscow, 117997

N. Egorova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: evkr@mail.ru
Rússia, Moscow, 117997

I. Kasheverov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Sechenov First Moscow State Medical University

Email: evkr@mail.ru
Rússia, Moscow, 117997; Moscow, 119992

V. Tsetlin

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: evkr@mail.ru
Rússia, Moscow, 117997

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Pleiades Publishing, Inc., 2018