The Role of GC-Rich Sequences from the Promoter Region of the  Drosophila melanogaster yellow  Gene in the Enhancer- Dependent Activation of Transcription

M. V. Kostyuchenko; A. K. Golovnin; P. G. Georgiev; L. S. Melnikova

doi:10.1134/S1607672918050071

The Role of GC-Rich Sequences from the Promoter Region of the Drosophila melanogaster yellow Gene in the Enhancer- Dependent Activation of Transcription

Autores: Kostyuchenko M.V.¹, Golovnin A.K.¹, Georgiev P.G.¹, Melnikova L.S.¹
Afiliações:
1. Institute of Gene Biology
Edição: Volume 482, Nº 1 (2018)
Páginas: 255-260
Seção: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212447
DOI: https://doi.org/10.1134/S1607672918050071
ID: 212447

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Resumo

It is shown that mutations in two GC-rich sequences (GC-boxes) from the promoter region of the yellow gene during enhancer-dependent transcription activation do not affect the basal level of the yellow gene transcription but destabilize the interaction between the enhancers and the promoter.