Translocation of Oligonucleotide–Oligosaccharide Complexes into Cells of the Brain
- Авторы: Dygalo N.N.1,2, Kalinina T.S.1,2, Lanshakov D.A.1
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Учреждения:
- Institute of Cytology and Genetics, Siberian Branch
- Novosibirsk State University
- Выпуск: Том 479, № 1 (2018)
- Страницы: 108-110
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212197
- DOI: https://doi.org/10.1134/S160767291802014X
- ID: 212197
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Аннотация
Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.
Об авторах
N. Dygalo
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Автор, ответственный за переписку.
Email: dygalo@bionet.nsc.ru
Россия, Novosibirsk, 6300900; Novosibirsk, 630090
T. Kalinina
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: dygalo@bionet.nsc.ru
Россия, Novosibirsk, 6300900; Novosibirsk, 630090
D. Lanshakov
Institute of Cytology and Genetics, Siberian Branch
Email: dygalo@bionet.nsc.ru
Россия, Novosibirsk, 6300900
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