Email this article Study of Biodistribution of the Modular Nanotransporters after Systemic Administration in Murine Cloudman S91 Melanoma Model
- Authors: Khramtsov Y.V.1, Ulasov A.V.1, Rosenkranz A.A.1,2, Georgiev G.P.1, Sobolev A.S.1,2
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Affiliations:
- Institute of Gene Biology
- Faculty of Biology
- Issue: Vol 478, No 1 (2018)
- Pages: 55-57
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212127
- DOI: https://doi.org/10.1134/S1607672918010131
- ID: 212127
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Abstract
The distribution of modular nanotransporters (MNTs) that are used to deliver drugs into melanoma cell nuclei after their intravenous administration into mice with Cloudman S91 melanoma was studied. The modification of MNTs with polyethylene glycol (PEG) of different length and their administration during the treatment with docetaxel, nitroglycerin, and excess of nonspecific MNTs leads to an improved accumulation of MNTs in the tummor. Among the variants studied, the MNT with attached PEG with Mr 40 kDa exhibited the best properties.
About the authors
Y. V. Khramtsov
Institute of Gene Biology
Email: alsobolev@yandex.ru
Russian Federation, Moscow, 119334
A. V. Ulasov
Institute of Gene Biology
Email: alsobolev@yandex.ru
Russian Federation, Moscow, 119334
A. A. Rosenkranz
Institute of Gene Biology; Faculty of Biology
Email: alsobolev@yandex.ru
Russian Federation, Moscow, 119334; Moscow, 119992
G. P. Georgiev
Institute of Gene Biology
Email: alsobolev@yandex.ru
Russian Federation, Moscow, 119334
A. S. Sobolev
Institute of Gene Biology; Faculty of Biology
Author for correspondence.
Email: alsobolev@yandex.ru
Russian Federation, Moscow, 119334; Moscow, 119992
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