The inhibitory effect of dinitrosyl iron complexes (NO donors) on myeloperoxidase activity

Abstract

The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated. It was shown that the enzyme MPO is the molecular target of DNICs. It was found that six DNICs inhibited the activity of MPO and one compound potentiated it. The evaluation of their efficiency showed that two DNICs effectively inhibited the activity of MPO by 50% at IC₅₀ = 2 × 10^–4 M and IC₅₀ = 5 × 10^–7 M.