Cloning, intracellular localization, and expression of the mammalian selenocysteine-containing protein SELENOI (SelI) in tumor cell lines
- Авторы: Varlamova E.G.1, Goltyaev M.V.1, Novoselov V.I.1, Fesenko E.E.1
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Учреждения:
- Institute of Cell Biophysics, Pushchino Branch
- Выпуск: Том 476, № 1 (2017)
- Страницы: 320-322
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211979
- DOI: https://doi.org/10.1134/S160767291705012X
- ID: 211979
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Аннотация
The intracellular localization of human selenoprotein SelI and the degree of expression of its gene in different human tumor cell lines were determined. It was found that the SelI protein is present in the nucleus, cytoplasm, and endoplasmic reticulum and is absent in the nucleolus. Since the oxidative stress caused by a sharp increase in the content of free radicals in the body is one of the causes of malignant transformation, the study of the role of the trace element selenium and selenocysteine-containing proteins as antioxidants in carcinogenesis is of great scientific interest.
Об авторах
E. Varlamova
Institute of Cell Biophysics, Pushchino Branch
Автор, ответственный за переписку.
Email: 1928lv@mail.ru
Россия, Pushchino, Moscow oblast, 142290
M. Goltyaev
Institute of Cell Biophysics, Pushchino Branch
Email: 1928lv@mail.ru
Россия, Pushchino, Moscow oblast, 142290
V. Novoselov
Institute of Cell Biophysics, Pushchino Branch
Email: 1928lv@mail.ru
Россия, Pushchino, Moscow oblast, 142290
E. Fesenko
Institute of Cell Biophysics, Pushchino Branch
Email: 1928lv@mail.ru
Россия, Pushchino, Moscow oblast, 142290
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