Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom


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Low-molecular-weight compounds with anticoagulant activity were isolated from the scorpion Heterometrus laoticus venom. The determination of the structure of the isolated compounds by nuclear magnetic resonance and mass spectrometry showed that one of the isolated compounds is adenosine, and the other two are dipeptides leucyl-tryptophan and isoleucyl-tryptophan. The anticoagulant properties of adenosine, which is an inhibitor of platelet aggregation, is well known, but its presence in scorpion venom is shown for the first time. The ability of leucyl-tryptophan and isoleucyl-tryptophan to slow down blood clotting and their presence in scorpion venom are also established for the first time.

作者简介

Tran Thien

Institute of Applied Materials Science; Graduate University of Science and Technology

Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City; Ho Chi Minh City

Hoang Anh

Institute of Applied Materials Science

Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City

Nguyen Trang

Faculty of Pharmacy

Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City

Phung Trung

Istitute of Chemical Technology

Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City

Nguyen Khoa

Institute of Applied Materials Science

Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City

A. Osipov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997

P. Dubovskii

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997

I. Ivanov

Istitute of Chemical Technology

Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City

A. Arseniev

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997

V. Tsetlin

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997

Yu. Utkin

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

编辑信件的主要联系方式.
Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997

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