Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom
- 作者: Thien T.V.1,2, Anh H.N.1, Trang N.T.3, Trung P.V.4, Khoa N.C.1, Osipov A.V.5, Dubovskii P.V.5, Ivanov I.A.4, Arseniev A.S.5, Tsetlin V.I.5, Utkin Y.N.5
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隶属关系:
- Institute of Applied Materials Science
- Graduate University of Science and Technology
- Faculty of Pharmacy
- Istitute of Chemical Technology
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- 期: 卷 476, 编号 1 (2017)
- 页面: 316-319
- 栏目: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211976
- DOI: https://doi.org/10.1134/S1607672917050052
- ID: 211976
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详细
Low-molecular-weight compounds with anticoagulant activity were isolated from the scorpion Heterometrus laoticus venom. The determination of the structure of the isolated compounds by nuclear magnetic resonance and mass spectrometry showed that one of the isolated compounds is adenosine, and the other two are dipeptides leucyl-tryptophan and isoleucyl-tryptophan. The anticoagulant properties of adenosine, which is an inhibitor of platelet aggregation, is well known, but its presence in scorpion venom is shown for the first time. The ability of leucyl-tryptophan and isoleucyl-tryptophan to slow down blood clotting and their presence in scorpion venom are also established for the first time.
作者简介
Tran Thien
Institute of Applied Materials Science; Graduate University of Science and Technology
Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City; Ho Chi Minh City
Hoang Anh
Institute of Applied Materials Science
Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City
Nguyen Trang
Faculty of Pharmacy
Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City
Phung Trung
Istitute of Chemical Technology
Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City
Nguyen Khoa
Institute of Applied Materials Science
Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City
A. Osipov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997
P. Dubovskii
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997
I. Ivanov
Istitute of Chemical Technology
Email: utkin@mx.ibch.ru
越南, Ho Chi Minh City
A. Arseniev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997
V. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997
Yu. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
编辑信件的主要联系方式.
Email: utkin@mx.ibch.ru
俄罗斯联邦, Moscow, 117997
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