Studying a novel ecdysone-dependent enhancer
- Авторлар: Nikolenko J.V.1, Krasnov A.N.1, Mazina M.Y.1, Georgieva S.G.1,2, Vorobyeva N.E.1
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Мекемелер:
- Institute of Gene Biology
- Engelhardt Institute of Molecular Biology
- Шығарылым: Том 474, № 1 (2017)
- Беттер: 236-238
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211925
- DOI: https://doi.org/10.1134/S160767291703022X
- ID: 211925
Дәйексөз келтіру
Аннотация
Earlier [4], we developed a two-stage scheme of the activation of expression of the ecdysone cascade gene ftz-f1 in Drosophila melanogaster S2 cells. In the first intron of the ftz-f1 gene, we found a binding site for the transcription activator DHR3. In this work, we studied the properties of this genomic element: the change in the histone modification level at different stages of transcription activation were analyzed, and data indicating the interaction of the intron element with the promoter were obtained. Taken together, the results of this study indicate that the studied genomic element exhibits the properties of an enhancer and functions at the stage of active gene transcription.
Авторлар туралы
J. Nikolenko
Institute of Gene Biology
Хат алмасуға жауапты Автор.
Email: julia.v.nikolenko@gmail.com
Ресей, Moscow, 119334
A. Krasnov
Institute of Gene Biology
Email: julia.v.nikolenko@gmail.com
Ресей, Moscow, 119334
M. Mazina
Institute of Gene Biology
Email: julia.v.nikolenko@gmail.com
Ресей, Moscow, 119334
S. Georgieva
Institute of Gene Biology; Engelhardt Institute of Molecular Biology
Email: julia.v.nikolenko@gmail.com
Ресей, Moscow, 119334; Moscow, 119991
N. Vorobyeva
Institute of Gene Biology
Email: julia.v.nikolenko@gmail.com
Ресей, Moscow, 119334
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