Eukaryotic elongation factor 2 kinase activation in M. soleus under 14-day hindlimb unloading of rats

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详细

Functional unloading of m. soleus of male Wistar rats was found to cause a reduction in protein synthesis. The level of phosphorylation of the translation elongation factor 2 (eEF2) and the eEF2 kinase (eEF2k) activity in m. soleus after 14 days of unloading were assessed. Rats were divided into the control group (C) and the group with hindlimb unloading for 14 days (HU14). The level of eEF2 phosphorylation in group HU14 was 80%, whereas in the control is was 40%. The indices of eEF2k expression and protein content in group HU14 increased compared to group C.

作者简介

Y. Lomonosova

Institute of Biomedical Problems

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Email: ylomonosova@mail.ru
俄罗斯联邦, Moscow, 123007

S. Belova

Institute of Biomedical Problems

Email: ylomonosova@mail.ru
俄罗斯联邦, Moscow, 123007

T. Mirzoev

Institute of Biomedical Problems

Email: ylomonosova@mail.ru
俄罗斯联邦, Moscow, 123007

I. Kozlovskaya

Institute of Biomedical Problems

Email: ylomonosova@mail.ru
俄罗斯联邦, Moscow, 123007

B. Shenkman

Institute of Biomedical Problems

Email: ylomonosova@mail.ru
俄罗斯联邦, Moscow, 123007

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