The effect of chlorpromazine on intracellular Ca 2+  concentration in macrophages

Z. I. Krutetskaya; L. S. Milenina; A. A. Naumova; S. N. Butov; V. G. Antonov; A. D. Nozdrachev

doi:10.1134/S1607672917030036

The effect of chlorpromazine on intracellular Ca²⁺ concentration in macrophages

Authors: Krutetskaya Z.I.¹, Milenina L.S.¹, Naumova A.A.¹, Butov S.N.¹, Antonov V.G.¹, Nozdrachev A.D.¹
Affiliations:
1. St. Petersburg State University
Issue: Vol 474, No 1 (2017)
Pages: 162-164
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211889
DOI: https://doi.org/10.1134/S1607672917030036
ID: 211889

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Abstract

Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca²⁺ concentration increase in macrophages due to Ca²⁺ mobilization from intracellular Ca²⁺ stores and subsequent Ca²⁺ entry from the external medium. Chlorpromazine-induced Ca²⁺ entry is inhibited by La³⁺ and 2-aminoethoxydiphenyl borate and is associated with Ca²⁺ store depletion.