Nuclear receptors EcR, Usp, E75, DHR3, and ERR regulate transcription of ecdysone cascade genes
- Авторлар: Mazina M.Y.1, Kocheryzhkina E.V.1, Nikolenko J.V.1, Krasnov A.N.1, Georgieva S.G.1,2, Vorobyeva N.E.1
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Мекемелер:
- Institute of Gene Biology
- Engelhardt Institute of Molecular Biology
- Шығарылым: Том 473, № 1 (2017)
- Беттер: 145-147
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211879
- DOI: https://doi.org/10.1134/S1607672917020144
- ID: 211879
Дәйексөз келтіру
Аннотация
We found that an increase in the expression level of E75, DHR3, and ERR increases the degree of activation of dhr3 and hr4 genes in Drosophila S2 cells. We also detected a repressing effect of these nuclear receptors on the basal transcription level of these genes. This is the first study to show the ability of nuclear receptors E75, DHR3, and ERR to function as activators or repressors depending on external conditions. We also confirmed the existence of the interaction of all studied nuclear receptors with the promoters of dhr3 and hr4 genes of the ecdysone cascade in vivo.
Авторлар туралы
M. Mazina
Institute of Gene Biology
Email: nvorobyova@gmail.com
Ресей, ul. Vavilova 34/5, Moscow, 119334
E. Kocheryzhkina
Institute of Gene Biology
Email: nvorobyova@gmail.com
Ресей, ul. Vavilova 34/5, Moscow, 119334
J. Nikolenko
Institute of Gene Biology
Email: nvorobyova@gmail.com
Ресей, ul. Vavilova 34/5, Moscow, 119334
A. Krasnov
Institute of Gene Biology
Email: nvorobyova@gmail.com
Ресей, ul. Vavilova 34/5, Moscow, 119334
S. Georgieva
Institute of Gene Biology; Engelhardt Institute of Molecular Biology
Email: nvorobyova@gmail.com
Ресей, ul. Vavilova 34/5, Moscow, 119334; ul. Vavilova 32, Moscow, 119991
N. Vorobyeva
Institute of Gene Biology
Хат алмасуға жауапты Автор.
Email: nvorobyova@gmail.com
Ресей, ul. Vavilova 34/5, Moscow, 119334
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