The reasons of Trithorax-like expression disturbance in Trl3609 allele of Drosophila melanogaster
- 作者: Karagodin D.A.1, Battulina N.V.1, Merkulova T.I.1, Baricheva E.M.1
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隶属关系:
- Institute of Cytology and Genetics, Siberian Branch
- 期: 卷 471, 编号 1 (2016)
- 页面: 443-446
- 栏目: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211784
- DOI: https://doi.org/10.1134/S1607672916060181
- ID: 211784
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详细
The regulatory region of the Trl gene was analyzed using the mutation Trl3609, resulting from the insertion of the P-element into the promoter region of the gene as well as mutations obtained on its basis. It is shown that two last transcription start sites, which are most often used in vitro in S2 cells, are almost not used in vivo. Experimental data indicate that transcription terminators in transposons play an important role in the decrease in the transcription level of the recipient gene.
作者简介
D. Karagodin
Institute of Cytology and Genetics, Siberian Branch
Email: barich@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
N. Battulina
Institute of Cytology and Genetics, Siberian Branch
Email: barich@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
T. Merkulova
Institute of Cytology and Genetics, Siberian Branch
Email: barich@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
E. Baricheva
Institute of Cytology and Genetics, Siberian Branch
编辑信件的主要联系方式.
Email: barich@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
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