mRNA expression profile of mouse oligodendrocytes in inflammatory conditions


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Аннотация

In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The results of this work are important for understanding the expression profile of oligodendrocytes under conditions of systemic inflammation in the central nervous system in multiple sclerosis as well as the mechanisms of cellular response to benztropine in light of its possible use for the treatment of multiple sclerosis.

Авторлар туралы

E. Kuzina

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: vera.knorre@gmail.com
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997

I. Glagoleva

Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University

Email: vera.knorre@gmail.com
Ресей, ul. Karla Marksa 74, Kazan, Tatarstan, 420055

E. Surina

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: vera.knorre@gmail.com
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997

V. Knorre

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Хат алмасуға жауапты Автор.
Email: vera.knorre@gmail.com
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997

A. Belogurov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University

Email: vera.knorre@gmail.com
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997; ul. Karla Marksa 74, Kazan, Tatarstan, 420055

A. Tonevitsky

BioKlinikum Scientific-Technical Center LLC

Email: vera.knorre@gmail.com
Ресей, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088

A. Gabibov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University; Faculty of Chemistry

Email: vera.knorre@gmail.com
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997; ul. Karla Marksa 74, Kazan, Tatarstan, 420055; Moscow, 119991

A. Kudriaeva

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: vera.knorre@gmail.com
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997

N. Khaustova

BioKlinikum Scientific-Technical Center LLC

Email: vera.knorre@gmail.com
Ресей, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088

D. Maltseva

BioKlinikum Scientific-Technical Center LLC

Email: vera.knorre@gmail.com
Ресей, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088

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