Glutamate release and uptake processes are altered in a new mouse model of amyotrophic lateral sclerosis
- Авторы: Grigoriev V.V.1, Efimova A.D.1, Ustyugov A.A.1, Shevchenko V.P.2, Bachurin S.O.1, Myasoedov N.F.2
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Учреждения:
- Institute of Physiologically Active Compounds
- Institute of Molecular Genetics
- Выпуск: Том 468, № 1 (2016)
- Страницы: 165-167
- Раздел: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211187
- DOI: https://doi.org/10.1134/S1607672916030017
- ID: 211187
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Аннотация
In this paper, we showed that in the cortex of mice expressing an abberant form of FUS protein that model amyotrophic lateral sclerosis (ALS), the processes of KCl-induced and basal [3H]glutamate release and uptake are altered at the presymptomatic stage as compared to the non-transgenic littermates. The change in these three parameters in transgenic animals causes excitotoxicity, which, in turn, may lead to massive loss of motor neurons and the onset of ALS symptoms.
Об авторах
V. Grigoriev
Institute of Physiologically Active Compounds
Email: efimova.a.d@gmail.com
Россия, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432
A. Efimova
Institute of Physiologically Active Compounds
Автор, ответственный за переписку.
Email: efimova.a.d@gmail.com
Россия, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432
A. Ustyugov
Institute of Physiologically Active Compounds
Email: efimova.a.d@gmail.com
Россия, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432
V. Shevchenko
Institute of Molecular Genetics
Email: efimova.a.d@gmail.com
Россия, pl. Akademika Kurchatova 46, Moscow, 123182
S. Bachurin
Institute of Physiologically Active Compounds
Email: efimova.a.d@gmail.com
Россия, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432
N. Myasoedov
Institute of Molecular Genetics
Email: efimova.a.d@gmail.com
Россия, pl. Akademika Kurchatova 46, Moscow, 123182
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