Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide

T. N. Shelykh; I. V. Rogachevsky; A. D. Nozdrachev; O. S. Veselkina; S. A. Podzorova; B. V. Krylov; V. B. Plakhova

doi:10.1134/S1607672916010191

Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide

Autores: Shelykh T.N.¹, Rogachevsky I.V.¹, Nozdrachev A.D.¹, Veselkina O.S.¹, Podzorova S.A.¹, Krylov B.V.¹, Plakhova V.B.¹
Afiliações:
1. Pavlov Institute of Physiology
Edição: Volume 466, Nº 1 (2016)
Páginas: 77-80
Seção: Biochemistry, Biophysics and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211007
DOI: https://doi.org/10.1134/S1607672916010191
ID: 211007

Citar

Texto integral

Acesso aberto
Acesso é fechado

Acesso está concedido
Acesso é fechado

Somente assinantes

Resumo
Sobre autores
Bibliografia
Arquivos suplementares
Estatísticas

Resumo

Using the whole-cell patch-clamp method, the ability of arginine-containing tripeptide Ac-RER-NH₂, dipeptide Ac-RR-NH₂, and free Arg molecule to modulate the membrane excitability of nociceptors was studied. Extracellular Ac-RER-NH₂ upon interaction with the outer membrane of the nociceptive neuron decreases the Z_eff value of the activation gating system of Na_v1.8 channels. Thus, the tripeptide Ac-RER-NH₂ can be considered as a new effective and safe analgesic.