A new principle for the diagnosis morphea in the onset of the disease
- 作者: Zaslavsky D.1, Sidikov A.2, Garyutkina L.1, Pyagai G.2, Alaeva M.2, Ibragimova N.2, Malikova N.2, Kozlova D.1
-
隶属关系:
- St. Petersburg State Pediatric Medical University
- Tashkent State Stomatology Institute
- 期: 卷 24, 编号 3 (2021)
- 页面: 263-274
- 栏目: DERMATOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/72328
- DOI: https://doi.org/10.17816/dv72328
- ID: 72328
如何引用文章
详细
BACKGROUND: Because of the low specificity morphea clinical manifestations in early stages, the differential diagnosis is difficult.
AIMS: The purpose of the research is to propose a new diagnostic method for early stages of localized scleroderma.
MATERIALS AND METHODS: During 2011–2020, 77 patients with clinical manifestations of morphea and 127 controls were examined and included in the study at the LenOblCenter. All participants were conducted a transcutaneous oximetry with the “TCM-400” Radiometer apparatus. The tissue oxygen perfusion (tcpO2) level from 40 to 50 mm Hg was considered as a reversible decrease, from 30 to 40 mm hg was a borderline decline and the value below 30 mm hg was critical. The following diagnostic skin biopsy was conducted in all 77 patients
RESULTS: Skin biopsy allowed to form 4 research groups: 40 patients with morphea, 12 patients with granuloma annulare, 15 patients with small plaque parapsoriasis and 10 individuals with large plaque parapsoriasis. 7 (17.5%) patients with morphea had normal tcpO2 values, 9 (22.5%) patients had significant decrease of tcpO2, 24 patients (60%) showed a reversible decrease of tcpO2. 3/12 (25%) patients with granuloma annulare and 1 patient (10%) with large plaque parapsoriasis had minor oxygen level decrease. Measurement on the healthy skin showed tcpO2 decrease in patients with comorbidities ― 3/77 (3.9%) in research group and 28/127 (22%) in controls.
CONCLUSIONS: Transcutaneous oximetry is a new perspective direction in the diagnostic algorithm of the morphea based on the pathogenesis and morphological features of the disease.
作者简介
Denis Zaslavsky
St. Petersburg State Pediatric Medical University
编辑信件的主要联系方式.
Email: venerology@gmail.com
ORCID iD: 0000-0001-5936-6232
SPIN 代码: 5832-9510
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 2 Litovskay street, 194100, Saint-PeterburgAkmal Sidikov
Tashkent State Stomatology Institute
Email: medik-85@bk.ru
ORCID iD: 0000-0002-0909-7588
MD, Dr. Sci. (Med.)
乌兹别克斯坦, TashkentLyubov Garyutkina
St. Petersburg State Pediatric Medical University
Email: liubovgariutkina.md@gmail.com
SPIN 代码: 3863-8682
Graduate Student
俄罗斯联邦, 2 Litovskay street, 194100, Saint-PeterburgGrigoriy Pyagai
Tashkent State Stomatology Institute
Email: gregbae@mail.ru
ORCID iD: 0000-0002-6456-6594
SPIN 代码: 2941-7297
MD, Cand. Sci. (Med.), Associate Professor
乌兹别克斯坦, TashkentMuyassar Alaeva
Tashkent State Stomatology Institute
Email: allaeva_m.d@mail.ru
ORCID iD: 0000-0002-5765-5425
MD, Cand. Sci. (Med.), Associate Professor
乌兹别克斯坦, TashkentNargiza Ibragimova
Tashkent State Stomatology Institute
Email: nargiza.is23@gmail.com
ORCID iD: 0000-0002-9715-9901
MD, Cand. Sci. (Med.), Associate Professor
乌兹别克斯坦, TashkentNilufar Malikova
Tashkent State Stomatology Institute
Email: dr.malikova@gmail.com
ORCID iD: 0000-0001-6964-8372
MD, Cand. Sci. (Med.), Associate Professor
乌兹别克斯坦, TashkentDarya Kozlova
St. Petersburg State Pediatric Medical University
Email: dashauchenaya@yandex.ru
ORCID iD: 0000-0002-6942-2880
SPIN 代码: 3783-8565
Student
俄罗斯联邦, 2 Litovskay street, 194100, Saint-Peterburg参考
- Rodionov AN, Nasyrov RA, Zaslavsky DV, et al. Diffuse connective tissue diseases: clinic and morphology of skin lesions. Saint Petersburg : Navoi; 2015. 160 p. (In Russ).
- Rodionov AN, Zaslavsky DV, Chuprov IN, et al. Dermatopatho-logy of inflammatory skin diseases. Tashkent; 2014. 208 p. (In Russ).
- Zhao B, Guan H, Liu JQ, et al. Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway. Int J Mol Med. 2017;39(1):153–159. doi: 10.3892/ijmm.2016.2816
- Zaslavsky DV, Sydikov AA, Garyutkina LV, et al. New aspects of the pathogenesis of limited scleroderma: a practical justification. Russian Journal of Skin and Venereal Diseases. 2020;23(4):227–237. (In Russ). doi: 10.17816/dv48907
- Mayes MD. Classification and epidemiology of scleroderma. Semin Cutan Med Surg. 1998;17:22–26. doi: 10.1016/s1085-5629(98)80058-8
- Arisi M, Cavazzana I, Cerutti ME, et al. Antibodies against antigens related to scleroderma in a cohort of patients with morphea. Ital Dermatol Venereol. 2018;153:451–458. doi: 10.23736/S0392-0488.16.05464-X
- Khatri S, Torok KS, Mirizio E, et al. Autoantibodies in morphea: an update. Front Immunol. 2019;10:1487. doi: 10.3389/fimmu.2019.01487
- Asano Y, Fujimoto M, Ishikawa O, et al. Diagnostic criteria, severity classification and guidelines of localized scleroderma. J Dermatol. 2018;45(7):755–780. doi: 10.1111/1346-8138.14161