Clinical symptoms of the effectiveness of combination therapy for onychomycosis of dermatomycete etiology

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

Onychomycosis is widespread all over the world. The choice of treatment tactics continues to be a difficult task for dermatologists. The use of combination therapy showed high clinical and mycological results of treatment, and also reduced the risk of relapses after discontinuation of therapy. Evaluation of the effectiveness of this therapy is based on knowledge of the reverse development of clinical symptoms.

作者简介

Alexey Yakovlev

Central State Medical Academy of the Administrative Department of the President of Russian Federation

编辑信件的主要联系方式.
Email: aby@rinet.ru
ORCID iD: 0000-0001-7073-9511

MD, PhD, Docent

俄罗斯联邦, Moscow

O. Golanova

Central State Medical Academy of the Administrative Department of the President of Russian Federation

Email: aby@rinet.ru
俄罗斯联邦, Moscow

参考

  1. Kaur R, Kashyap B, Bhalla P. Onychomycosis – epidemiology, diagnosis and management. Indian J Med Microbiol. 2008;26(2):108-16. doi: 10.4103/0255-0857.40522.
  2. Bodman MA, Krishnamurthy K. Onychomycosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan. 2020 Aug 8. PMID: 28722883.
  3. Kasikhina EI, Yakovlev AB. Onychomycosis. Attending Physician. Russian Journal. 2012;(5):49-53. (in Russian)
  4. Saliy ЕА. Onychomycosis. Epidemiology, etiopathogenesis, treatment Dermatovenerology. Cosmetology. Sexual Pathology. Ukrainian Journal. 2011;(1-4):110-4. (in Russian)
  5. Sergeev AYu. Update views on pathogenesis of onychomycosis. International Journal of Immunopathology, Allergology, Infectology. Russian Journal. 2000;(1):100-9. (in Russian)
  6. Sergeev YuV, Mokina EV, Sergeev AYu, Burtseva GN, Baranova MO, Savchenko NV, Sergeev VYu. Local and combined therapy of onychomycosis. Moscow: National Academy of Mycology; 2015. (in Russian)
  7. Rashid A, Scott E, Richardson MD. Early events in the invasion of the human nail plate by Trichophyton mentagrophytes. Br J Dermatol. 1995;133(6):932-40.
  8. Gerasimchuk EV. the role of Modern topical treatment to skin and nail fungal infections in older adults. Clinical gerontology. Russian Journal. 2016;(7-8):63-5. (in Russian)
  9. Potekaev NN, Molochkov VA, Shakhova LM, Shishkova MV. Combined therapy of onychomycosis: approaches and prospects. Advances in Medical Mycology. Russian Journal. 2004;(4):307-8. (in Russian)
  10. Ryder NS. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992;126(Suppl.39):2-7.
  11. Sigurgeirsson B, Olafsson JH, Steinsson JB, Pau C, Billstein S, Evans GV. Long-term effectiveness of treatment with terbinafine vs itraconazole in onychomycosis: a 5-year blinded prospective follow-up study. Arch Dermatol. 2002;138(3):353-7.
  12. Baran R, Hay RJ, Garduno JI. Review of antifungal therapy and the severity index for assessing onychomycosis: part I. J Dermatolog Treat. 2008;19(2):72-81.
  13. Grover C, Khurana A. An update on treatment of onychomycosis. Mycoses. 2012;55(6):541-51. doi: 10.1111/j.1439-0507.2012.02199.x.
  14. Bhatta AK, Keyal U, Wang X, Gellen E. A review of the mechanism of action of lasers and photodynamic therapy for onychomycosis. Lasers Med Sci. 2017;32(2):469-74.
  15. Potekaev NN, Kruglova LS. Lasers in Dermatology and Cosmetology. Moscow: Alkor Publishers; 2018. (in Russian)
  16. Kawa N, Lee KC, Anderson RR, Garibyan L. Onychomycosis: A review of new and emerging topical and device-based treatments. J Clin Aesthet Dermatol. 2019;12(10):29-34.
  17. Sergeev YuV, Sergeev VYu. What is a combination theatment and how it may be used in onychomycosis. Herald of Venerology and Dermatology. Russian Journal. 2011;(5):125-30. (in Russian)
  18. Lecha M, Alsina M, Torres Rodriguez JM, de Erenchun FR, Mirada A, Rossi AB. An open-label, multicenter study of the combination of amorolfine nail lacquer and oral itraconazole compared with oral itraconazole alone in the treatment of severe toenail onychomycosis. Curr Ther Res. 2002;63(6):366-79.
  19. Leelavathi M, Noorlaily MN. Onychomycosis nailed. Malays Fam Physician. 2014;9(1):2-7.
  20. Rukavishnikova VM. Mycosis of the feet. Moscow: AlexCom; 2003. (in Russian)

补充文件

附件文件
动作
1. JATS XML
2. Fig. 1. Distal normotrophic type of nail lesion: onychorexis is visible. Local therapy with amorolfine varnish started.

下载 (228KB)
3. Fig. 2. Normotrophic distal-lateral type of nail damage to the 1st toe of the right foot and the combined white superficial and hypertrophic type of nail damage to the 3rd, 4th, 5th toes.

下载 (111KB)
4. Fig. 3. Hypertrophic total type of nail lesion, "tower nails".

下载 (219KB)
5. Fig. 4. Successful treatment of onychomycosis. A demarcation zone in the form of a rainbow stripe and residual subungual hyperkeratosis are visible.

下载 (226KB)
6. Fig. 5. The beginning of the formation of the demarcation zone in normotrophic distal onychomycosis.

下载 (165KB)

版权所有 © Eco-Vector, 2020


 


##common.cookie##