Acne, the microbiome and innate immunity


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详细

In the laste years several articles focalized on human microbioma - the microorganisms from skin, mucosae, bowel - and on its role in chronic inflammatory diseases of the skin as acne, rosacea, atopic dermatitis, seborrheic dermatitis. In this article the authors present an update on particular acne skin’s microbioma, on innate immunity in acne and new physiopathology mecanisms described in inflammatory process in acne, and at the end we present in vitro, ex vivo and in vivo studies on the microbioma modulation and microbiofilm of pathogenic ribotypes of P. acnes leading to a significant improvement of acne in a series of 74 acne patients.

作者简介

Marius-Anton Ionescu

University Paris VII

Email: dr.toni.ionescu@gmail.com
MD, PhD, Dermatology Outpatient Clinic University Hospital “Saint-Louis” Paris VII 1, Avenue Claude Vellefaux, 75745 Paris cedex 10, France

M. Feuiolley

Universite de Rouen

Laboratoire de microbiologie, signaux et microenvironnement EA 4312 Франция

J. Enault

Universite de Rouen

Laboratoire de microbiologie, signaux et microenvironnement EA 4312 Франция

P. Wolkenstein

University Paris XII

Dermatology Department, University Hopsital Henry Mondor Creteil

G. Robert

R&D, Laboratoires Dermatologiques d’Uriage

Научно-исследовательское отделение Neuilly-sur-Seine, France

L. Lefeuvre

R&D, Laboratoires Dermatologiques d’Uriage

Научно-исследовательское отделение Neuilly-sur-Seine, France

参考

  1. Lomholt H.B., Kilian M. Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. PLoS One. 2010; 5(8): e12277. doi: 10.1371/journal.pone.0012277.
  2. Brzuszkiewicz E., Weiner J., Wollherr A., Thurmer A., Hupeden J., Lomholt H.B., et al. Comparative genomics and transcriptomics of Propionibacterium acnes. PLoS One. 2011; 6(6):e21581. doi: 10.1371/journal.pone.0021581.
  3. Fitz-Gibbon S., Tomida S., Chiu B.H., Nguyen L., Du C., Liu M., et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J. Invest. Dermatol. 2013; 133(9): 2152-60. doi: 10.1038/jid.2013.21.
  4. Wolkenstein P., Grob J.J., Bastuji-Garin S., Ruszczynski S., Roujeau J.C., Revuz J.; Société Française de Dermotologie. French people and skin diseases: results of a survey using a representative sample. Arch. Dermatol. 2003; 139(12): 1614-9.
  5. Di Landro A., Cazzaniga S., Parazzini F., Ingordo V., Cusano F., Atzori L., et al.; GISED Acne Study Group. Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. J. Am. Acad. Dermatol. 2012; 67(6): 1129-35. doi: 10.1016/j.jaad.2012.02.018.

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