SKIN INVOLVEMENT IN CHRONIC LYMPHOID LEUKEMIA


如何引用文章

全文:

详细

About 25% patients with CLL develop skin lesions. These lesions can be classified as specific (including skin infiltration by leukemic cells and the cutaneous form of Richter’s syndrome), secondary cutaneous tumors, and concomitant cutaneous diseases. Leukemic infiltration of the skin in CLL patients is called specific in volvement of the skin (SIS) or skin leukemia. Many authors attribute the unfavorable prognosis to the CLL transformation with specific infiltration of the skin into Richter’s syndrome and to emergence of SIS before the diagnosis of CLL. The risk of cancers in CLL patients is 3-fold higher, of skin cancer 8-fold higher than in normal subjects. The most frequent secondary tumors of the skin in CLL are basal-cell carcinoma, squamous-cell carcinoma, melanoma, Merkel’s tumor. Nonspecific cutaneous changes vary greatly and are detected in 30—50% CLL patients. The most prevalent secondary changes in the skin in CLL are those of infectious nature. These patients can also develop hypersensitivity reactions to insect bites, generalized itching, exfoliative erythroderma, nodular erythema, paraneoplastic pemphigus, bullous pemphigoid, toxi coderma, etc.

作者简介

Elena Muravyova

I.M.Setchenov First Moscow State Medical University

Email: elene_mur@mail.ru
Кафедра кожных и венерических болезней им. В.А.Рахманова Moscow, Russia

Olga Olisova

I.M.Setchenov First Moscow State Medical University

доктор мед. наук, профессор Moscow, Russia

Evgeniy Nikitin

Hematological Center

кандидат мед. наук. Moscow, Russia

参考

  1. Vyas N., Hassan A. Recent advances in chronic lymphocytic leukemia. Indian J. Cancer. 2012; 49(1): 137—43.
  2. Kalil N., Cheson B.D. Management of chronic lymphocytic leukaemia. Drugs Aging. 2000; 16(1): 9—27.
  3. Nikitin E.A. Chronic lymphocytic leukemia: a new understanding of the biology of chronic lymphocytic leukemia, and new approaches to the therapy. Oncohaematology (Hronicheskij limfolejkoz: novoe v ponimanii biologii hronicheskogo limfolejkoza, novye podhody k lecheniju. Onkogematologija). 2006; 1—2: 124—7.
  4. Robak T., Kantarjian H., Robertson L., Lerner S., Keating M.J. Therapy of chronic lymphocytic leukaemia with purine nucleoside analogues: facts and controversies. Drugs Aging. 2005; 22(12): 983—1012.
  5. Mehrany K., Byrd D.R., Roenigk R.K., Weenig R.H., Phillips P.K., Nguyen T.H., et al. Lymphocytic infiltrates and subclinical epithelial tumor extension in patients with chronic leukemia and solid-organ transplantation. Dermatol Surg. 2003; 29(2): 129—34.
  6. Katinas A.I., Sigova T.A. Clinical features of patients with skin lesions in generalized lymphoma and chronic lymphocytic leukemia. Therapeutic Archives. (Kliniko-anamnesticheskie osobennosti u bol’nyh s porazheniem kozhi pri generalizovannyh limfomah i hronicheskom limfolejkoze. Terapevticheskij arhiv). 2000; 10: 57—9
  7. Lezvinskaya E.M., Vavilov A.M. Lymphoproliferative tumors of the skin. Rukovodstvo dlya vrachey. Moscow: Prakticheskaya Meditsina (Limfoproliferativnye opuholi kozhi. Rukovodstvo dlja vrachej. Moskva: Prakticheskaja medicina); 2010. (in Russian)
  8. Cerroni L., Zenahlik P., Hofler G., Kaddu S., Smolle J., Kerl H. Specific cutaneous infiltrates of B-cell chronic lymphocyticleukemia: а clinicopathologic and prognostic study of 42patients. Am. J. Surg. Pathol. 1996; 20(8):1000—10.
  9. Agnew K.L., Ruchlemer R., Catovsky D., Matutes E., Bunker C.B. Cutaneous findings in chronic lymphocyticleukaemia. Br. J. Dermatol. 2004; 150(6): 1129—35.
  10. Cabuk M., Inanir I., Turkdogan P., Ceylan C., Degirmenci M., Turel A., et al. Cyclic lymphocytic vasculitis associated with chronic lymphocytic leukemia. Leuk. Lymphoma. 2004; 45(4): 811—3.
  11. Doutre M.S., Beylot-Barry M., Beylot C., Dubus P., Lafont M.E., Belleannee G., et al.Cutaneous localization of chronic lymphocytic leukemia at the site of chickenpox. J. Am. Acad. Dermatol. 1997; 36(1): 98—9.
  12. Paydas S., Zorludemir S. Leukaemia cutis and leukaemicvasculitis. Br. J. Dermatol. 2000; 143(4): 773—9.
  13. Hamada T., Setoyama M., Katahira Y., Furuno T., Fujiyoshi T., Sonoda S., et al. Differences in HTLV-I integration patterns between skin lesions and peripheral blood lymphocytes of HTLV-I seropositive patients with cutaneous lymphoproliferative disorders. J. Dermatol. Sci. 1992; 4(2): 76—82.
  14. Desch J.K., Smoller B.R. The spectrum of cutaneous disease in leukemias. J. Cutan Pathol. 1993; 20(5): 407—10.
  15. Smoller B.R., Warnke R.A. Cutaneous infiltrate of chronic lymphocytic leukemia and relationship to primary cutaneous epithelial neoplasms. J. Cutan. Pathol. 1998; 25(3): 160—4.
  16. Butler D.F., Berger T.G., Rodman O.G. Leukemia cutis mimicking stasis dermatitis. Cutis. 1985; 35(1): 47—8.
  17. Lamotkin I.A. Skin lesions in lymphoma malignancies. Dis. Moscow (Porazhenie kozhi pri zlokachestvennyh limfomah. Dis. Moskva); 2004.
  18. Celerier P., Bureau B., Litoux P., Dreno B. keratinocyte-lymphocyte interaction in cutaneous T-cell lymphoma. Arch. Dermatol. 1997; 133(7): 837—40.
  19. Colburn D.E., Welch M.A., Giles F.J. Skin infiltration with chronic lymphocytic leukemia is consistent with a good prognosis. Hematology. 2002; 7(3):187—8.
  20. Su W.P. Clinical, histopthologic and immunohistochemical correlations in leukemia cutis. Semin. Dermatol. 1994; 13(3): 223—30.
  21. Davis M.D., Perniciaro C., Dahl P.R., Randle H.W., McEvoy M.T., Leiferman K.M. Exaggerated arthropod-bite lesions in patients with chronic lymphocytic leukemia: a clinical, histopathologic, and immunopathologic study of eight patients. J. Am. Acad. Dermatol. 1998; 39(1): 27—35.
  22. Simon C.A., Su W.P., Li C.Y. Subungual leukemia cuttis. Int. J. Dermatol. 1990; 29(9): 636—9.
  23. Kazakov D.V., Belousova I.E., Michaelis S., Palmedo G., Samtsor A.V., Kempf W. Unusual manifestations of specific cutaneous involvement by B-cell chronic lymphocytic leukemia: spontaneous regression with scar formation. Dermatology. 2003; 207(1): 111—5.
  24. Zimmer M., Bornkessel A., Hahnfeld S., Weyers W. ‘‘Specific’’ cutaneous infiltrate of B-cell chronic lymphocytic leukemia at the site of a florid herpes simplex infection. J. Cutan. Pathol. 2005; 32(8): 581—4.
  25. Aberer W., Zonzits E., Soyer H.P., Kerl H. Post-zoster-specific skin infiltrates in chronic lymphatic leukemia. Hautarzt. 1990; 41(8): 455—7.
  26. Cerroni L., Hofler G., Back B., Wolf P., Maier G., Kerl H. Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia (B-CLL) at sites typical for Borrelia burgdoferi infection. J. Cutan. Pathol. 2002; 29(3): 142—7.
  27. Ratnam K.V., Kohr C.J., Su W.P. Leukemia cutis. Dermatol. Clin. 1994; 12(2): 419—31.
  28. Watson K.M., Mufti G., Salisbury J.R., du Vivier A.W., Creamer D. Spectrum of clinical presentation, treatment and prognosis in a series of eight patients with leukaemia cutis. Clin. Exp. Dermatol. 2006; 31(2): 218—21.
  29. Buechner S.A., Li C.Y., Su W.P. Leukemia cutis: a histopathologic study of 42 cases. Am. J. Dermatopathol. 1985; 7(2): 109—19.
  30. Kaddu S., Smolle J., Cerroni L., Kerl H. Prognostic evaluation of specific cutaneous infiltrates in B-chronic lymphocytic leukemia. J. Cutan. Pathol. 1996; 23(6): 487—94.
  31. Han T., Rai K.R. Chronic lymphocytic leukemia. In: Henderson E.S., Lister T.A., eds. Leukemia. Phildelphia: WB Saunders; 1990.
  32. Varkonyi J., Zalatnai A., Timar J., Matolocsi A., Falus A., Benesath M., et al. Secondary cutaneous infiltration in B-cell chronic lymphocytic leukemia. Acta Haematol. 2000; 103(2): 116—21.
  33. Porter W.M., Sidwell R.U., Catovsky D., Bunker C.B. Cutaneous presentation of chronic lymphatic leukaemia and response to ultraviolet B phototherapy. Br. J. Dermatol. 2001; 144(5): 1092—4.
  34. Zarco C., Lahuerta-Palacios J.J., Borrego L., Toscano R., Gil R., Iglesias L. Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement — cutaneous presentation of Richter’s syndrome. Clin. Exp. Dermatol. 1993; 18(3): 263—7.
  35. Ilushkina E.A., Zvonkov E.E., Kravchenko C.K. Primary B-cell lymphomas of the skin. Hematology and Transfusiology (Pervichnye V-kletochnye limfomy kozhi. Gematologija i tpansfuziologija). 2011; 1: 22—7. (in Russian)
  36. Yamazaki M.L., Lum C.A., Izumi A.K. Primary cutaneous Richter syndrome: prognostic implications and review of the literature. J. Am. Acad. Dermatol. 2009; 60(1): 157—61. doi: 10.1016/j.jaad.2008.07.017.
  37. Ratnavel R.C., Dunn-Walters D.K., Boursier L., Frazer-Andrews E., Orchard G., Russell-Jones R. B-cell lymphoma associated with chronic lymphatic leukaemia: two cases with contrasting aggressive and indolent behaviour. Br. J. Dermatol. 1999; 140(4): 708—14.
  38. Robak T. Second malignancies and Richter’s syndrome in patients with chronic lymphocytic leukemia. Hematology. 2004; 9(5—6): 387—400.
  39. Manusow D., Weinerman B.H. Subsequent neoplasia in chronic lymphocytic leukemia. JAMA. 1975; 223(1): 262—9.
  40. Molica S. Second neoplasms in chronic lymphocytic leukemia: incidence and pathogenesis with emphasis on the role of different therapies. Leuk. Lymphoma. 2004; 46(1): 49—54.
  41. Travis L.B., Curtis R.E., Hankey B.F., Fraumeni J.F.Jr. Second cancers in patients with chronic lymphocytic leukemia. J. Natl. Cancer Inst. 1992; 84(18): 1422—7.
  42. McKenna D.B., Doherty V.R., McLaren K.M., Hunter J.A. Malignant melanoma and lymphoproliferative malignancy: is there a sharedaetiology? Br. J. Dermatol. 2000; 143(1): 171—3.
  43. Davidovitz Y., Ballin A., Meytes D. Fluare-up squamous cell carcinoma of skin-following fludarabine therapy for chronic lymphocytic leukemia. Acta Haematol. 1997; 98(1): 44—6.
  44. Ziprin P., Smith S., Salerno G., Rosin R.D. Two cases of Merkel cell tumour arising in patients with chronic lymphocytic leukaemia. Br. J. Dermatol. 2000; 142(3): 525—8.
  45. Larsen C.R., Hansen P.B., Clausen N.T. Aggressive growth of epithelial carcinomas following treatment with nucleoside analogues. Am. J. Hematol. 2002; 70(1): 48—50.
  46. Hartley B.E., Searle A.E., Breach N.M., Rhys-Evans P.H., Heuk J.M. Aggressive cutaneous squamous cell carcinoma of the head and neck in patients with chronic lymphoctic leukemia. J. Laryngol. Otol. 1996; 110(7): 694—5.
  47. Grudeva-Popova J. Skin lesions in hematological malignancies. Journal of Dermatology and Venereology. (Grudeva-Popova Zh. Kozhnye projavlenija pri gemoblastozah. Vestnik dermatologii i venerologii) 1990; 1: 68—70. (in Russian) [Грудева-Попова Ж. Кожные проявления при гемобластозах. Вестник дерматологии и венерологии. 1990; 1: 68—70.]
  48. Morrison V.A. The infectious complications of chronic lymphocytic leukemia. Semin. Oncol. 1998; 25(1): 98—106.
  49. Rashid K., Ng R., Mastan A., Sager D., Hirschman R. Accelerated growth of skin carcinoma following fludarabine therapy for chronic lymphocytic leukemia. Leuk. Lymphoma. 2005; 46(7): 1051—5.
  50. Cocuroccia B., Gisondi P., Gubinelli E., Girolomoni G. An itchy vesiculobullous eruption in a patient with chronic lymphocytic leukemia. Int. J. Clin. Pract. 2004; 58(12): 1177—9.
  51. Punit D., Wadhwa A., Vicki A. Morrison infectious complications of chronic lymphocytic leukemia. Semin. Oncol. 2006; 33(2): 240—9.
  52. Robak E., Gora-Tybor J., Kordek R., Wawrzyniak E., Bartkowiak J., Bednarek A., et al. Richter syndrome first manifesting as cutaneous B-cell lymphoma clonally distinct from primary B-cell chronic lymphocytic leukaemia. Br. J. Dermatol. 2005; 153(4): 833—7.
  53. Ljungman P. Viral Infections: current diagnosis and treatment. Hematol. J. 2004; 5(3): 63—8.
  54. Morrison V.A. The infectious complications of chronic lymphocytic leukemia. Semin. Oncol. 1998; 25(1): 98—106.
  55. Chilukuri S., Rosen T. Management of acyclovir-resistant herpes simplex virus. Dermatol. Clin. 2003; 21(2): 311—20.
  56. Locksley R.M., Flournoy N., Sullivan K.M., Meyers J.D. Infection with varicella-zoster virus after marrow transplantation. J. Infect. Dis. 1985; 152(6): 1172—81.
  57. Barzilai A., Shpiro D., Goldberg I., Yacob-Hirsch Y., Diaz-Cascajo C., Meytes D. Insect bite-like reaction in patients with hematologic malignant neoplasms. Arch. Dermatol. 1999; 135(12): 1503—7.
  58. Dodiuk-Gad R.P., Dann E.J., Bergman R. Insect bite like reaction associated with mantle cell lymphoma: a report of two cases and review of the literature. Int. J. Dermatol. 2004; 43(10): 754—8.
  59. Pederson J., Carganello J., van der Weyden M.B. Exaggerate reaction to insect bites in patients with chronic lymphocytic leukemia: clinical and histological findings. Pathology. 1990; 22(3): 141—3.
  60. Weed R.I. Exaggerated delayed hypersensitivity to mosquito bites in chronic lymphocytic leukemia. Blood. 1965; 26(1): 257—68.
  61. Kolbusz R.V., Micetich K., Armin A.R., Massa M.C. Exaggerated response to insect bites: an unusual cutaneous manifestation of chronic lymphocytic leukemia. Int. J. Dermatol. 1989; 28(3): 186—7.
  62. Mitteldorf C., Tronnier M., Merz H., Haenssle H.A., Bertsch H.P., Schön M.P., Kaune K.M. Insect bite-like reactions in a patient with B-cell chronic lymphocytic leukaemia: fluorescence in situ hybridization analysis revealed neoplastic B cells within the skin infiltrate. Br. J. Dermatol. 2012; 167(4): 937—63. doi: 10.1111/j.1365-2133.2012.10966.x.

版权所有 © Eco-Vector, 2013


 


##common.cookie##