Experience of using the 1,5% Tetranyl U cream in patients with tinea corporis and tinea cruris

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BACKGROUND: Over the past ten years, there has been a persistent increase in the resistance of dermatophytes to antifungal drugs. The development of new drugs and the evaluation of the effectiveness of medicines is a priority in mycology.

AIMS: Evaluation of the effectiveness and safety of using the cream containing Tetranyl U and 10% urea in the treatment of tinea corporis and tinea cruris.

MATERIALS AND METHODS: The study included 30 patients with a laboratory-confirmed diagnosis of tinea corporis and tinea cruris of mild to moderate severity. Patients were recommended to use the cream which was applied to the lesions 2 times a day for 3 weeks. The evaluation of the severity the course of mycosis and the effectiveness of the cream was carried out by calculating a 4-point PGA (Physician Global Assessment) before treatment and after 3 weeks of using the cream.

RESULTS: According to the results of the study, the clinical efficacy was 81.8%. Mycological response (negative direct microscopy + mycological culture) was achieved in 82.8% of patients.

CONCLUSION: The cream containing Tetranyl U showed good efficacy and tolerability in the treatment of tinea corporis and tinea cruris, which is confirmed by the results of clinical and microbiological studies.

作者简介

Ivan Maximov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

编辑信件的主要联系方式.
Email: maximov.is@mail.ru
ORCID iD: 0000-0003-2850-2910

Assistant

俄罗斯联邦, Moscow

Eugenia Petukhova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: petuxova0304@gmail.com
ORCID iD: 0000-0002-9396-4874

Student

俄罗斯联邦, Moscow

参考

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1. JATS XML
2. Fig. 1. Dynamics of PGA index.

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3. Fig. 2. Patient K., 71 years old. Diagnosis: Tinea corporis caused by Trichophyton rubrum: а ― before treatment; b ― after 3 weeks of therapy.

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4. Fig. 3. Patient Zh., 48 years old. Diagnosis: Candidiasis of large folds: а ― before treatment; b ― after 3 weeks of therapy.

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5. Fig. 4. Patient A., 78 years old. Diagnosis: Tinea cruris: а ― before treatment; b ― after 3 weeks of therapy.

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版权所有 © Maximov I.S., Petukhova E.V., 2022

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