Comparative study of the effectiveness of anti-aging cream with hydroquinone and broadband pulsed light in melasma
- 作者: Sidorenko O.1, Opruzhenkova E.1, Arkatova E.1
-
隶属关系:
- Rostov State Medical University
- 期: 卷 25, 编号 3 (2022)
- 页面: 219-227
- 栏目: DERMATOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/108987
- DOI: https://doi.org/10.17816/dv108987
- ID: 108987
如何引用文章
详细
BACKGROUND: Melasma is one of the most common types of hyperpigmentation that significantly impair the quality of life of patients. Despite the availability of effective means and methods of hyperpigmentation therapy, to date there are no clear protocols for the management of patients with melasma.
AIM: of the study was to evaluate the clinical efficacy of anti-aging cream (2% hydroquinone and 0.025% tretinoin) as part of the complex therapy of melasma in women.
MATERIALS AND METHODS: The article presents data on the comparative evaluation of the clinical efficacy of anti-aging cream (2% hydroquinone and 0.025% tretinoin) in the treatment of melasma in 30 women aged 35 to 46 years. The patients were divided into 3 groups: group 1 (n=10) received external therapy with anti-aging cream once a day at night for 3 months, group 2 (n=10) received phototherapy with Lumenis M22 Universal IPL Module 1 time a month for 3 months, group 3 (n=10) ― anti-aging cream + phototherapy with Lumenis M22 Universal IPL 1 time per month for 3 months.
Before the start of therapy, the severity of melasma was determined for all patients based on the calculation of the MASI index (Melasma Area and Severity Index) and the MSS index (Melasma Severity Scale), the level of melanin in the skin was also measured by the method of mexametry, the impact of melasma on the quality of life (QOL) was assessed based on the MELASQoL questionnaire. The effectiveness of therapy was evaluated based on the dynamics of changes in the MASI index and the parameters of the mex before treatment and after 29 days of therapy. Comparison of MELASQoL indicators was carried out before treatment, after 29 days of therapy and 3 months.
RESULTS: Studies have shown that the most pronounced clinical efficacy, namely, a decrease in the severity of melasma, a decrease in the amount of melanin in the skin and an improvement in QOL was observed in 3 group of patients who received combined therapy with anti-aging cream and phototherapy with Lumenis M22 Universal IPL 1 time per month for 3 months. Also, in group 1 patients who received only external therapy with anti-aging cream, there was a significant decrease in the level of melanin in the skin and an improvement in the quality of life after 29 days of therapy and after 3 months of treatment.
CONCLUSIONS: The combination of anti-aging cream with hydroquinone with broadband pulsed lights is an effective method of correcting melasma.
作者简介
Olga Sidorenko
Rostov State Medical University
Email: ola_ps@mail.ru
ORCID iD: 0000-0002-7387-2497
SPIN 代码: 2209-0521
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, Rostov-on-DonEvgeniya Opruzhenkova
Rostov State Medical University
编辑信件的主要联系方式.
Email: eva_derm@mail.ru
ORCID iD: 0000-0002-5830-1768
SPIN 代码: 6516-3262
MD, Cand. Sci. (Med.), Associate Professor
俄罗斯联邦, Rostov-on-DonEkaterina Arkatova
Rostov State Medical University
Email: arcatova@gmail.com
ORCID iD: 0000-0001-6966-4153
SPIN 代码: 7478-5709
Assistant Lecturer
俄罗斯联邦, Rostov-on-Don参考
- Krichigina TN, Grushin VN, Belikova IS. Melanocytes: structure, functions, detection methods, role in skin pathology. Bulletin Voronezh State Med University. 2007;6(4):5–16. (In Russ).
- Goldsmith LA, Katz SI, Gilcrest BA. Fitzpatrick’s Dermatology in Clinical Practice: in 3 vol. Ed. by N.N. Potekayev, A.N. Lvov. Vol. 1. Moscow: Panfilov Publishing House; 2015. Р. 849–915. (In Russ).
- Olisova OY, Andreeva EV. Once again about the problem of hyperpigmentation. Russ J Skin and Venereal Diseases. 2014;(2):20–24. (In Russ).
- Kruglova LS, Ikonnikova EV. Skin hyperpigmentation: modern views on etiology and pathogenesis (part 1). Russ J Skin Venereal Diseases. 2017;20(3):178–183. (In Russ). doi: 10.18821/1560-9588-2017-20-3-178-183
- Kwon SH, Hwang YJ, Lee SK, Park KC. Heterogeneous pathology of melasma and its clinical implications. Int J Mol Sci. 2016;17(6):pii E824. doi: 10.3390/ijms17060824
- Kruglova LS, Ikonnikova EV. Skin hyperpigmentation: a modern view on correction methods (part 2). Russ J Skin Venereal Diseases. 2017;20(4):248–251. (In Russ). doi: 10.18821/1560-9588-2017-20-4-248-251
- Sharuchanova АА. Clinical and laboratory substantiation of differentiated therapy of melasma in women [dissertation abstract]. Moscow; 2019. 29 р.
- Heger PG. Children’s dermatology. Transl. from German, ed. A.A. Kubanova, A.N. Lvov. Moscow: BINOM; 2013. Р. 452–476. (In Russ).
- Vashi NA, Kundu RV. Facial hyperpigmentation: causes and treatment. Br J Dermatol. 2013;169(3):41–56. doi: 10.1111/bjd.12536
- Kuradovets AA. Development and validation of the Russian version of the MELASQoL-RUS questionnaire for cosmetology practice. Health Education XXI Century. 2018;20(4)79–83. (In Russ). doi: 10.26787/nydha-2226-7425-2018-20-4