Role of oxidative stress in development of epithelial tumors of the skin in dermatoheliosis


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Abstract

Oxidative stress, developing after exposure to UV radiation of spectra A and B, leads to the formation of active oxygen species. This event leads to numerous negative consequences - formation of single-strand ruptures in the DNA and formation ofprotein suturing, promoting the emergence of mutations and triggering carcinogenesis. It also initiates the cascade of signal routes, mediated by stimulation of many receptor families: epidermal growth factor receptor, fibroplastic growth factor receptor, cytokine (TNFa and IL-1) receptors, and Fas receptor. In addition, a special mutant protein p53 is detected in epidermal cells chronically exposed to UV radiation. This protein can determine the initial stages of carcinogenesis or emerge during tumor growth, maintaining tumor acquisition of new aggressive characteristics and drug resistance.

About the authors

Elena S. Snarskaya

I.M. Setchenov First Moscow State Medical University

Email: snarskaya-dok@mail.ru
MD, PhD, DSc, prof. 119991, Moscow, Russia

S. B Tkachenko

I.M. Setchenov First Moscow State Medical University

Research Center 119991, Moscow, Russia

E. V Kuznetsova

I.M. Setchenov First Moscow State Medical University

Email: kuznetsova-ek@bk.ru
Research Center 119991, Moscow, Russia

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