MORPHOLOGY OF ACTINIC KERATOSIS


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Abstract

Actinic keratosis (AK) is a precancer disease of the skin, emerging in skin sites exposed to the sun. It is characterized by local intraepidermal dysplasia of different severity (KIN I — slight, KIN II — moderate, and KIN III — severe). We studied the distribution and morphology of AK histological types. The study was carried out on 30 biopsy specimens from patients. The study showed that the main morphological signs of AK in the epidermis were keratinocyte dysplasia and hyperparakeratosis; changes in the derma were presented by elastosis in all cases. The most prevalent morphological types of solar keratosis were hypertrophic, atrophic, and bovenoid variants. Slight dysplasia (KIN I) was found mainly in atrophic AK, moderate (KIN II) in hypertrophic, and severe (KIN III) only in bovenoid AK.

About the authors

A. N Khlebnikova

ФППОВ ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России

Кафедра кожных и венерических болезней

M. A Bobrov

ФППОВ ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России

Кафедра кожных и венерических болезней

E. V Selezneva

ГУ МОНИКИ им. М.Ф. Владимирского

Email: selezneva-elena@mail.ru
патологоанатомическое отделение

K. A Changlyan

ФППОВ ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России

Кафедра кожных и венерических болезней

References

  1. Ackerman A.B. // Arch. Dermatol. — 2003. — Vol. 139. — P. 1216—1217.
  2. Alam M. // Adv. Stud. Med. — 2006. — Vol. 6, N 8A. — P. 785-790.
  3. Bagazgoitia L., Cuevas J., Juarranz A. // J. Eur. Acad. Dermatol. Venereol. — 2010. — Vol. 24, N 2. — P. 228—230.
  4. Billano Retna A., Little Walter P. // J. Am. Acad. Dermatol. — 1982. — Vol. 7. — P. 484—489.
  5. Cho C.G., Jo H.Y., Choi H.C. et al. // Acta Dermatol. Venerol. — 1999. — Vol. 79. — P 278—280.
  6. Cockerell C.J., Wharton J.R. // J. Drugs Dermatol. — 2005. — Vol. 4. — Р. 462—467.
  7. Goette D.K. // Arch. Dermatol. — 1980. — Vol. 116. — P. 780—782.
  8. Hashimoto K., Mehregan A.H. Tumors of the Epidermis. — Stoneham: Inc. Butterworth Publishers; 1990.
  9. Ishida H., Kumakiri M., Ueda K. et al. // Eur. J. Histochem. — 2001. — Vol. 45. — P 177—190.
  10. Landry D., Stinson W.A., Perkins D.G. et al. // Histopathology. — 2002. — Vol. 41. — P. 331—336.
  11. Lever L., Marks R. // Br. J. Dermatol. — 1989. — Vol. 120. — P. 383—389.
  12. Lever’s Histopathology of the Skin. — 9th Ed. — Philadelphia: Lippincott Williams and Wilkins; 2005.
  13. Lober B.A., Lober C.W. // South Med. J. — 2000. — Vol. 93. — P. 650—655.
  14. Montagna W., Kirchner S., Carlisle K. // J. Am. Acad. Dermatol. — 1989. — Vol. 21. — P. 907—918.
  15. Mostow E.N., Johnson T.M. // Arch. Dermatol. — 1992. — Vol. 128. — Р 560—561.
  16. Sarma D.P., Sharma P. // Inter. J. Dermatol. — 2006. — Vol. 4, N 1. http://www.scribd.com/doc/22920860/Dermato-pathology
  17. Suchniak J.M., Baer S., Goldberg L.H. // J. Am. Acad. Dermatol. — 1997. — Vol. 37. — P. 392—394.
  18. Uchiyama N., Shindo Y. // J. Dermatol. (Tokyo). — 1986. — Vol. 13. — P. 377—380.

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