The experience of follicular occlusion syndrome treatment with tumor necrosis factor inhibitors
- Authors: Teplyuk N.P.1, Konchina S.A.1, Pirogova A.S.1
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Affiliations:
- The First Sechenov Moscow State Medical University (Sechenov University)
- Issue: Vol 26, No 2 (2023)
- Pages: 157-170
- Section: DERMATOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/132604
- DOI: https://doi.org/10.17816/dv133626
- ID: 132604
Cite item
Abstract
Follicular occlusion syndrome consists of several conditions that share similar pathophysiology involving infundibular follicular occlusion and secondary inflammatory cascade. This syndrome includes hidradenitis suppurativa, dissecting cellulitis of the scalp, acne conglobata and pilonidal sinus. They can develop independently or as a component of a syndrome in different combinations.
We are the first to present a clinical case of follicular occlusion tetrad and intermediate therapy outcome with tumor necrosis factor inhibitors. We also provide a full and updated review of the literature on the etiology and pathogenesis, diagnosis and treatment of similar syndromic conditions.
Currently, there is no reliable algorithm of treatment for patients with follicular occlusion syndrome, which underlines the importance of further studies. The presented clinical case confirms the need for timely administration of genetically-engineered biological drugs to patients with diseases of the follicular occlusion group (before sinus tract formation).
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##article.viewOnOriginalSite##About the authors
Natalya P. Teplyuk
The First Sechenov Moscow State Medical University (Sechenov University)
Email: teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800
SPIN-code: 8013-3256
MD, Dr. Sci. (Med.), Professor
Russian Federation, 8-2 Trubetskaya street, 119991 MoscowSvetlana A. Konchina
The First Sechenov Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: konchina.svetlana@yandex.ru
ORCID iD: 0000-0003-2038-1472
Student
Russian Federation, 8-2 Trubetskaya street, 119991 MoscowAnna S. Pirogova
The First Sechenov Moscow State Medical University (Sechenov University)
Email: annese@mail.ru
ORCID iD: 0000-0002-2246-1321
SPIN-code: 1419-2147
MD, Graduate Student
Russian Federation, 8-2 Trubetskaya street, 119991 MoscowReferences
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