Development of scalded skin syndrome in an adult patient with acquired epidermolysis bullosa after long-term treatment with methotrexate
- Authors: Olisova O.Y.1, Teplyuk N.P.1, Ignatiev D.V.1, Dunaeva E.R.1
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Affiliations:
- The First Sechenov Moscow State Medical University (Sechenov University)
- Issue: Vol 26, No 1 (2023)
- Pages: 41-49
- Section: DERMATOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/132593
- DOI: https://doi.org/10.17816/dv114845
- ID: 132593
Cite item
Abstract
A clinical case of a patient with epidermolysis bullosa acquisita, which is a rare autoimmune disease ― 0.17–0.26 cases per 1 million population, with the development, most likely against the background of long-term cytostatic therapy with methotrexate, develops staphylococcal scalded skin syndrome is presented.
Staphylococcal scalded skin syndrome is a lesion that appears in 0.09–0.56 cases per 1 million and is predominantly observed in newborns and children under 5 years of age, and cases in adults are usually associated with immunosuppression, human immunodeficiency virus / acquired immunodeficiency syndrome, severe renal failure or malignant neoplasms.
The article presents literature data on the etiology and pathogenesis of the presented diseases, features of differential diagnosis, description of clinical and laboratory criteria, on the basis of which diagnoses are made.
This clinical case is of interest to dermatologists, as it describes the scalded skin syndrome, which is rare in everyday practice, in a patient with acquired epidermolysis bullosa, which, despite ongoing therapy, has a risk of death of up to 65%.
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##article.viewOnOriginalSite##About the authors
Olga Yu. Olisova
The First Sechenov Moscow State Medical University (Sechenov University)
Email: olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN-code: 2500-7989
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowNataliа P. Teplyuk
The First Sechenov Moscow State Medical University (Sechenov University)
Email: teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800
SPIN-code: 8013-3256
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowDmitry V. Ignatiev
The First Sechenov Moscow State Medical University (Sechenov University)
Email: dmitrywork@list.ru
ORCID iD: 0000-0001-8751-3965
SPIN-code: 6743-7960
MD
Russian Federation, MoscowEkaterina R. Dunaeva
The First Sechenov Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: dunaevaer@gmail.com
ORCID iD: 0000-0002-5458-4991
SPIN-code: 3551-6329
MD
Russian Federation, MoscowReferences
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