Delayed inflammatory reaction of hyaluronic acid fillers against the background of flu-like illness
- Authors: Ikonnikova E.V.1,2, Manturova N.E.2,3, Kruglova L.S.1,2
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Affiliations:
- Central State Medical Academy of Department of Presidential Affairs
- Institute of Plastic Surgery and Cosmetology
- The Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 24, No 1 (2021)
- Pages: 93-100
- Section: COSMETOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/61472
- DOI: https://doi.org/10.17816/dv61472
- ID: 61472
Cite item
Abstract
Traditionally, it is considered that inflammatory reactions with delayed onset that occur due to the use of fillers based on hyaluronic acid (HA) are included in the category of rare complications. But in recent years, due to the increasing popularity of injection procedures, such reactions have become more common, which attracts the attention of both the scientific community and clinicians.
This article presents a clinical case of a late inflammatory response, describes the diagnosis and tactics of therapy, and provides an overview of the etiology, pathogenesis, diagnosis, and therapy of such reactions. 7 months ago, HA filler was injected into the area of both tear troughs. 3 months after the procedure, the patient underwent acute respiratory viral infection, against which for the first time she noted the sudden appearance of inflammation. 3 months after the first episode of an inflammatory reaction in the tear troughs, against the background of acute pharyngitis, its relapse occurred, accompanied by similar symptoms.
Similar inflammatory reactions can occur with any HA filler, but their frequency may vary depending on various factors. Timely detection and proper treatment can successfully eliminate the inflammatory reaction within a few days.
Keywords
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##article.viewOnOriginalSite##About the authors
Evgeniya V. Ikonnikova
Central State Medical Academy of Department of Presidential Affairs; Institute of Plastic Surgery and Cosmetology
Author for correspondence.
Email: evikonnikova@bk.ru
ORCID iD: 0000-0002-8813-9132
SPIN-code: 9210-8396
Cand. Sci. (Med.), Associate Professor
Russian Federation, 19, Marshala Timoshenko str., Moscow, 121359; MoscowNataliya E. Manturova
Institute of Plastic Surgery and Cosmetology; The Russian National Research Medical University named after N.I. Pirogov
Email: manturovane@mail.ru
ORCID iD: 0000-0003-4281-1947
SPIN-code: 5232-0412
Dr. Sci. (Med.), Professor
Russian Federation, 19, Marshala Timoshenko str., Moscow, 121359; MoscowLarisa S. Kruglova
Central State Medical Academy of Department of Presidential Affairs; Institute of Plastic Surgery and Cosmetology
Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265
SPIN-code: 1107-4372
Dr. Sci. (Med.), Professor
Russian Federation, 19, Marshala Timoshenko str., Moscow, 121359; MoscowReferences
- Procedural Statistics. Cosmetic surgery national data bank statistics. Surgery ASoAP; 2019. Available from: http://www.surgery.org/media/statistics
- Alijotas-Reig J, Fernández-Figueras MT, Puig L. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum. 2013;43(2):241–258. doi: 10.1016/j.semarthrit.2013.02.001
- Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol. 2013;6:295–316. doi: 10.2147/CCID.S50546
- DeLorenzi C. Complications of injectable fillers, part I. Aesthet Surg J. 2013;33(4):561–575. doi: 10.1177/1090820X13484492
- Ikonnikova EV, Kruglova LS. Recurrent inflammatory reaction after correction of the nasolacrimal furrow with a filler based on hyaluronic acid: a clinical case. Clinical Dermatology and Vene-reology. 2020;19(4):558–662. (In Russ).
- Rzany B, DeLorenzi C. Understanding, avoiding, and managing severe filler complications. Plast Reconstr Surg. 2015;136(5):196–203. doi: 10.1097/PRS.0000000000001760
- Alijotas-Reig J, Fernández-Figueras MT, Puig L. Late-onset inflammatory adverse reactions related to soft tissue filler injections. Clin Rev Allergy Immunol. 2013;45(1):97–108. doi: 10.1007/s12016-012-8348-5
- Dayan SH. Complications from toxins and fillers in the dermatology clinic: recognition, prevention, and treatment. Facial Plast Surg Clin North Am. 2013;21(4):663–673. doi: 10.1016/j.fsc.2013.07.008
- Arron ST, Neuhaus IM. Persistent delayed-type hypersensitivity reaction to injectable non-animal-stabilized hyaluronic acid. J Cosmet Dermatol. 2007;6(3):167–171. doi: 10.1111/j.1473-2165.2007.00331.x
- Rongioletti F. Granulomatous reactions from aesthetic dermal micro-implants. Ann Dermatol Venerol. 2008;135(1 Pt 2):1S59–65. doi: 10.1016/S0151-9638(08)70213-8
- Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Plast Surg Nurs. 2015;35(1):13–32. doi: 10.1097/PSN.0000000000000087
- Beleznay K, Carruthers JD, Carruthers A, et al. Delayed-onset nodules secondary to a smooth cohesive 20 mg/ml hyaluronic acid filler: cause and management. Dermatol Surg. 2015;41(8):929–939. doi: 10.1097/DSS.0000000000000418
- De Boulle K, Heydenrych I. Patient factors influencing dermal filler complications: prevention, assessment, and treatment. Clin Cosmet Investig Dermatol. 2015;8:205–214. doi: 10.2147/CCID.S80446
- Sadeghpour M, Quatrano NA, Bonati LM, et al. Delayed-onset nodules to differentially crosslinked hyaluronic acids: comparative incidence and risk assessment. Dermatol Surg. 2019;45(8):1085–1094. doi: 10.1097/DSS.0000000000001814
- Ozturk CN, Li Y, Tung R, et al. Complications following injection of soft-tissue fillers. Aesthet Surg J. 2013;33(6):862–877. doi: 10.1177/1090820X13493638
- Lemperle G, Gauthier-Hazan N. Foreign body granulomas after all injectable dermal fillers: part 2. Treatment options. Plast Reconstr Surg. 2009;123(6):1864–1873. doi: 10.1097/PRS.0b013e3181858f4f
- Bhojani-Lynch T. Late-onset inflammatory response to hyaluronic acid dermal fillers. Plast Reconstr Surg Glob Open. 2017;5(12):e1532. doi: 10.1097/GOX.0000000000001532
- Al-Shraim M, Jaragh M, Geddie W. Granulomatous reaction to injectable hyaluronic acid (Restylane) diagnosed by fine needle biopsy. J Clin Pathol. 2007;60(9):1060–1061. doi: 10.1136/jcp.2007.048330
- Artzi O, Cohen JL, Dover JS, et al. Delayed inflammatory reactions to hyaluronic acid fillers: a literature review and proposed treatment algorithm. Clin Cosmet Investig Dermatol. 2020;13:371–378. doi: 10.2147/CCID.S247171
- Lee JM, Kim YJ. Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Arch Plast Surg. 2015;42(2):232–239. doi: 10.5999/aps.2015.42.2.232
- Hatcher JL, Goldman ND. Recognition and treatment of non-infectious hyaluronic acid reactions. J Dermatolog Treat. 2014;25(6):513–515. doi: 10.3109/09546634.2012.703307
- Artzi O, Loizides C, Verner I, Landau M. Resistant and recurrent late reaction to hyaluronic acid-based gel. Dermatol Surg. 2016;42(1):31–37. doi: 10.1097/DSS.0000000000000562
- Bitterman-Deutsch O, Kogan L, Nasser F. Delayed immune mediated adverse effects to hyaluronic acid fillers: report of five cases and review of the literature. Dermatol Rep. 2015;7(1):5851. doi: 10.4081/dr.2015.5851
- Sanchez O, Rodriguez-Sureda V, Dominguez C, et al. Study of biomaterial-induced macrophage activation, cell-mediated immune response and molecular oxidative damage in patients with dermal bioimplants. Immunobiology. 2012;217(1):44–53. doi: 10.1016/j.imbio.2011.08.003
- Romagnoli M, Belmontesi M. Hyaluronic acid-based fillers: theory and practice. Clin Dermatol. 2008;26(2):123–159. doi: 10.1016/j.clindermatol.2007.09.001
- Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008;10(1):35–42. doi: 10.1080/14764170701774901
- Friedman PM, Mafong EA, Kauvar AN, Geronemus RG. Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation. Dermatol Surg. 2002;28(6):491–494. doi: 10.1046/j.1524-4725.2002.01251.x
- Tseng CH, Chen AM, Chang JY. Hyaluronic acid injection-induced delayed-onset foreign body granuloma. J Dental Sci. 2015;10(3):341–343. doi: 10.1016/j.jds.2015.03.008
- Cassuto D, Sundaram H. A problem-oriented approach to nodular complications from hyaluronic acid and calcium hydroxylapatite fillers: classification and recommendations for treatment. Plast Reconst Surg. 2013;132(2):48–58. doi: 10.1097 / PRS.0b013e31829e52a7
- Ikonnikova EV, Kruglova LS, Zubarev AV, et al. Application of ultrasound for differential diagnosis of complications after contour injection plastic surgery: a clinical case. Plastic Surgery and Aesthetic Medicine. 2019;(3):70–74. (In Russ). doi: 10.17116/plast.hirurgia201903170
- Ikonnikova EV, Zubarev AV, Potkin SB, Garankin NA. Ultrasound diagnostics and therapy in cosmetology practice. Physiotherapist. Russian Journal. 2019;(4):72–75. (In Russ).
- Chiang YZ, Pierone G, Al-Niaimi F. Dermal fillers: pathophysiology, prevention and treatment of complications. J Eur Acad Dermatol Venereol. 2017;31(3):405–413. doi: 10.1111/jdv.13977
- Hartmann D, Ruzicka T, Gauglitz GG. Complications associated with cutaneous aesthetic procedures. J Dtsch Dermatol Ges. 2015;13(8):778–786. doi: 10.1111/ddg.12757
- Snozzi P, van Loghem JA. Complication management following rejuvenation procedures with hyaluronic acid fillers – an algorithm-based approach. Plas Reconstr Surg Glob Open. 2018;6(12):e2061. doi: 10.1097/GOX.0000000000002061
- Ikonnikova EV, Kruglova LS. Determined immunosuppressive response after introduction of fillers based on hyaluronic acid: clinical case. Pharmacy. 2019;(8):88–91. doi: 10.18565/pharmateca. (In Russ).