ANTIBACTERIAL PEPTIDES IN THE TREATMENT OF ACNE VULGARIS PATIENTS


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Abstract

Acne vulgaris is a multifactorial disease. Besides genomic regulatory mechanism and among numerous triggering factors Cutibacterium acnes is considered as one of the main pathogenic factors, that can activate the human humoral and cellular immune system, exhibiting a robust proinflammatory activity. The article provides an updated review of the data on current antimicrobial peptides that could be used as potential therapeutic agents against microorganisms located in the skin and related to acne disease, which embraces promise to solve the problem of antimicrobial resistance of cutibacterium acnes. The positive results of regular investigation of clinical efficacy of topical antimicrobial peptides GDP-20 in 33 acne vulgaris patients are presented.

About the authors

Ziyuan Ma

Department of Skin and Venereal Diseases of Institute of Clinical Medicine of I.M. Sechenov of First Moscow State

Email: stephanie92@foxmail.com
Department of skin and venereal diseases of I.M. Sechenov of First Moscow State Medical University, Moscow, 119991, Russian Federation Moscow, 119991, Russian Federation

N. G Kochergin

Department of Skin and Venereal Diseases of Institute of Clinical Medicine of I.M. Sechenov of First Moscow State

Moscow, 119991, Russian Federation

References

  1. Admani S., Barrio V.R. Evaluation and treatment of acne from infancy to preadolescence. Dermatol.Ther. (Review). 2013; 26(6): 462-6.
  2. Bhate K., Williams H.C. Epidemiology of acne vulgaris. Br. J. Dermatol. (Review). 2013; 168(3): 474-85.
  3. Kanokvalai Kulthanan, Sukhum Jiamton, Renu Kittisarapong. Dermatology life quality index in Thai patients with acne. Siriraj Med. J. 2007; 59(1): 3-7. https://pdfs.semanticscholar.org/a971/f0da658a787c83bfa0b3cf5260a286970a91.pdf
  4. Олисова О.Ю., ред. Кожные и венерические болезни. М.: Практическая медицина; 2019.
  5. Bhambri S., Del Rosso J.Q., Bhambri A. Pathogenesis of acne vulgaris: recent advances. J. Drugs Dermatol. 2009; 8(7): 615-8.
  6. Kim J. Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses. Dermatology. 2005; 211(3): 193-8.
  7. Tom W.L., Barrio V.R. New insights into adolescent acne. Curr. Opin. Pediatr. 2008; 20(4): 436-40.
  8. Самцов А.В., Аравийская Е.Р. Федеральные клинические рекомендации по ведению больных акне. Москва: Российское общество дерматовенерологов и косметологов; 2013. https://mzdrav.rk.gov.ru/file/Akne_05052014_Klinicheskie_rekomendacii.pdf
  9. Kong H.H., Segre J.A. Skin microbiome: looking back to move forward. J. Invest. Dermatol. 2012; 132(3, Pt 2): 933-9.
  10. Nakano T., Yoshino T., Fujimura T., Arai S., Mukuno A., Sato N., Katsuoka K. Reduced expression of dermcidin, a peptide active against propionibacterium acnes, in sweat of patients with acne vulgaris. Acta Derm. Venereol. 2015; 95(7): 783-6.
  11. Ajesh K., Sreejith K. Peptide antibiotics: an alternative and effective antimicrobial strategy to circumvent fungal infections. Peptides. 2009; 30(5): 999-1006.
  12. Reddy K.V., Yedery R.D., Aranha C. Antimicrobial peptides: premises and promises. Int. J. Antimicrob. Agents. 2004; 24(6): 536-47.
  13. Beylot C., Auffret N., Poli F., Claudel J.P., Leccia M.T., Del Giudice P., Dreno B. Propionibacterium acnes: an update on its role in the pathogenesis of acne. J. Eur. Acad. Dermatol. Venereol. 2014; 28(3): 271-8.
  14. Deslouches B., Di Y.P. Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications. Oncotarget. 2017; 8(28): 46635-51.
  15. Ross J.I., Snelling A.M., Carnegie E., Coates P., Cunliffe W.J., Bettoli V., et al. Antibioti-cresistant acne: lessons from Europe. Br. J. Dermatol. 2003; 148(3): 467-78.
  16. Han R., Blencke H.M., Cheng H., Li C. The antimicrobial effect of CEN1HC-Br against Propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris. Peptides. 2018; 99: 36-43.
  17. Li C., Haug T., Moe M.K., Styrvold O.B., Stensvag K. Centrocins: isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis. Dev. Comp. Immunol. 2010; 34(9): 959-68.
  18. Bjorn C., Hakansson J., Myhrman E., Sjostrand V., Haug T., Lindgren K., et al. Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis. AMB Express. 2012; 2(1): 67.
  19. Kim J., Ochoa M.T., Krutzik S.R., Takeuchi O., Uematsu S., Legaspi A.J., et al. Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses, J. Immunol. 2002; 169(3): 1535-41.
  20. Marcinkiewicz M., Majewski S. The role of antimicrobial peptides in chronic inflammatory skin diseases. Postepy Dermatol. Alergol. 2016; 33(1): 6-12.
  21. Zhang L.J., Gallo R.L. Antimicrobial peptides. Curr. Biol. 2016; 26(1): R14-9.
  22. Borovaya A., Dombrowski Y., Zwicker S., Olisova O., Ruzicka T., Wolf R., et al. Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. Arch. Dermatol. Res. 2014; 306(8): 689-700.
  23. Epand R.M., Vogel H.J. Diversity of antimicrobial peptides and their mechanisms of action. Biochim. Biophys. Acta. 1999; 1462(1-2): 11-28.
  24. Friedrich C.L., Moyles D., Beveridge T.J., Hancock R.E. Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria. Antimicrob. Agents Chemother. 2000; 44(8): 2086-92.
  25. Scott M.G., Hancock R.E. Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit. Rev. Immunol. 2000; 20(5): 407-431.
  26. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002; 415(6870): 389-95.
  27. McInturff J.E., Wang S.J., Machleidt T., Lin T.R., Oren A., Hertz C.J., et al. Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes. J. Invest. Dermatol. 2005; 125(2): 256-63.
  28. Ма Цзыюань, Кочергин Н.Г. Наружные антимикробные пептиды в комбинированный терапии вульгарных угрей. Сборник тезисов Рахмановской конференции. Москва; 2020: 88-89. www.medprint.ru
  29. McNicol P.J., Rubinchik E., Cameron D., Pawlak S.K., Guarna M.M. Antimicrobial and anti-inflammatory peptides. Patent publication number US20030148945A1 (2003, United States). https://patents.google.com/patent/US20030148945
  30. Sader H.S., Fedler K.A., Rennie R.P., Stevens S., Jones R.N. Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity. Antimicrob. Agents Chemother. 2004; 48(8): 3112-8.
  31. Hoban D.J., Witwicki E., Zhanel G.C., Palatnick L., Friedland H.D. In: Materials of 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, California, 2002, Sept 27-30. 2002: abstr. E-1647.
  32. Stenger S., Hanson D.A., Teitlebaum R., Dewan P., Niazi K.R., Froelich C.J., et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998; 282(5386): 121-5.
  33. Олисова О.Ю., Снарская Е.С. Отчет о применении препаратов серии АС Сontrol на основе антимкробного пептида AcnotideTM в топической терапии пациентов с акне. Москва; 2017. https://procosm.com.
  34. Wang Y., Zhang Z., Chen L., Guang H., Li Z., Yang H., et al. Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. PLoS One. 2011; 6(7): e22120.
  35. Pan C.Y., Chen J.Y., Lin T.L., Lin C.H. In vitro activities of three synthetic peptides derived from epinecidin-1 and an anti-lipopolysaccharide factor against Propionibacterium acnes, Candida albicans, and Trichomonas vaginalis. Peptides. 2009; 30(6): 1058-68.
  36. Yoon J.Y., Kwon H.H., Min S.U., Thiboutot D.M., Suh D.H. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. J. Invest. Dermatol. 2013; 133(2): 429-40.
  37. Кочергин Н.Г., Самгин М.А., Монахов С.А., Игнатьев Д.В. Дерматологический индекс акне. Эстетическая медицина. 2004; 3(1): 62-6.

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